Wang Xin, Wang Huan, You Jianjun, Zheng Ruobing, Xu Yihao, Fan Fei
Department of Rhinoplasty, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Pediatr. 2022 Aug 24;10:979345. doi: 10.3389/fped.2022.979345. eCollection 2022.
Considerable studies have focused mainly on the facial deformity of Tessier No.0 cleft with a bifid nose, but the deformity of the skull is not well understood. Therefore, our study aimed to explore the evolution of cranial dysmorphology and the chronology of Tessier No.0 cleft with a bifid nose, by three-dimensional measurements.
Ninety-six non-surgical patients and computed tomographic scans were included (Tessier No.0 cleft with a bifid nose, = 48; controls, = 48) and divided into five age subgroups. Craniofacial cephalometric measurements were analyzed by Mimics software.
The widening of nasal bone was the most remarkable and persistent from 2 years old appropriately. The overall cranial base length in patients compared with controls increased 11.8% ( < 0.01) on average. The middle and posterior cranial fossa increasing accounted for most of this change. The cranial base angles also showed increased obviously. By analyzing the linear of the nasopharynx and respiratory tract, it was found that its development did not affect respiration.
The cranial base deformity of Tessier No.0 cleft with a bifid nose consists of the whole skull base and particularly the middle and posterior cranial base length increase. At the same time, there may be late closure of the spheno-occipital synchondrosis and sella displacement. We believe this study is unique in providing valuable data for elucidating the pathological and morphological abnormalities of skull base development in Tessier No.0 cleft with a bifid nose.
大量研究主要聚焦于伴有鼻裂的Tessier 0号腭裂的面部畸形，但颅骨畸形尚未得到充分了解。因此，我们的研究旨在通过三维测量探索颅骨形态异常的演变以及伴有鼻裂的Tessier 0号腭裂的发生时间顺序。
纳入96例非手术患者及其计算机断层扫描图像（伴有鼻裂的Tessier 0号腭裂患者48例；对照组48例），并分为五个年龄亚组。通过Mimics软件分析颅面测量数据。
鼻骨增宽从2岁左右开始最为显著且持续存在。与对照组相比，患者的颅底总长度平均增加了11.8%（P<0.01）。中颅窝和后颅窝的增加占了这一变化的大部分。颅底角也明显增大。通过分析鼻咽部和呼吸道的长度，发现其发育不影响呼吸。
伴有鼻裂的Tessier 0号腭裂的颅底畸形包括整个颅底，尤其是中颅底和后颅底长度增加。同时，蝶枕软骨结合可能延迟闭合以及蝶鞍移位。我们认为本研究为阐明伴有鼻裂的Tessier 0号腭裂颅底发育的病理和形态异常提供了有价值的数据，具有独特性。
