Zhang Xue, Xu Xiang-Fei, Jin Jie
Department of Infectious Diseases, The Affiliated Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Front Pediatr. 2022 Aug 26;10:951127. doi: 10.3389/fped.2022.951127. eCollection 2022.
Rotavirus vaccination has been proven to effectively protect against rotavirus gastroenteritis. However, there are concerns about the relationship between rotavirus vaccination and the risk of autoimmune disorders. Thus, we conducted a systematic review and meta-analysis to comprehensively assess the association between rotavirus vaccination and type 1 diabetes (T1D) or celiac disease (CD) risk.
A systematic review and meta-analysis were conducted to evaluate the type 1 diabetes or celiac disease associated with rotavirus vaccination. The following journal databases were searched to identify potential studies for inclusion: PubMed, Embase, and Cochrane Library databases.
Seven articles involving more than 5,793,055 children were included. Our results showed that rotavirus vaccination does not alter the subsequent risk of T1D (RR 0.94, 95% CI: 0.82-1.09) or CD (RR 0.86, 95% CI: 0.64-1.17) after vaccination. Furthermore, the risk of T1D was not increased or decreased for children fully exposed to rotavirus vaccination (RR 0.86, 95% CI, 0.54-1.36) and for children partially exposed to rotavirus vaccination (RR 1.05, 95% CI, 0.87-1.26). However, younger (<5 years) vaccinated children at the end of study (RR 0.84, 95% CI = 0.75-0.95) may be at a lower risk for T1D than older (≥5 years) vaccinated children (RR 0.93, 95% CI, 0.81-1.07).
The findings of this study suggest that rotavirus vaccination does not appear to be associated with T1D or CD in children. The protective effect of rotavirus vaccination on T1D may be presented by time dependent.
轮状病毒疫苗已被证明能有效预防轮状病毒肠胃炎。然而，人们担心轮状病毒疫苗与自身免疫性疾病风险之间的关系。因此，我们进行了一项系统评价和荟萃分析，以全面评估轮状病毒疫苗接种与1型糖尿病（T1D）或乳糜泻（CD）风险之间的关联。
进行了一项系统评价和荟萃分析，以评估与轮状病毒疫苗接种相关的1型糖尿病或乳糜泻。检索了以下期刊数据库，以确定可能纳入的研究：PubMed、Embase和Cochrane图书馆数据库。
纳入了7篇涉及超过5793055名儿童的文章。我们的结果表明，轮状病毒疫苗接种不会改变接种后T1D（风险比[RR]0.94，95%置信区间[CI]：0.82-1.09）或CD（RR 0.86，95%CI：0.64-1.17）的后续风险。此外，完全接种轮状病毒疫苗的儿童（RR 0.86，95%CI，0.54-1.36）和部分接种轮状病毒疫苗的儿童（RR 1.05，95%CI，0.87-1.26）的T1D风险没有增加或降低。然而，研究结束时年龄较小（<5岁）的接种疫苗儿童（RR 0.84，95%CI = 0.75-0.95）患T1D的风险可能低于年龄较大（≥5岁）的接种疫苗儿童（RR 0.93，95%CI，0.81-1.07）。
本研究结果表明，轮状病毒疫苗接种似乎与儿童的T1D或CD无关。轮状病毒疫苗对T1D的保护作用可能具有时间依赖性。
