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人参皂苷Rh2对紫外线照射后人皮肤成纤维细胞线粒体自噬的潜在抑制作用。

The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts.

作者信息

Lee Hyunji, Kong Gyeyeong, Park Jisoo, Park Jongsun

机构信息

Department of Pharmacology, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.

Department of Medical Science, College of Medicine, Chungnam National University, Daejeon, Republic of Korea.

出版信息

J Ginseng Res. 2022 Sep;46(5):646-656. doi: 10.1016/j.jgr.2022.02.001. Epub 2022 Feb 9.

DOI:10.1016/j.jgr.2022.02.001
PMID:36090683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9459079/
Abstract

BACKGROUND

In addition to its use as a health food, ginseng is used in cosmetics and shampoo because of its extensive health benefits. The ginsenoside, Rh2, is a component of ginseng that inhibits tumor cell proliferation and differentiation, promotes insulin secretion, improves insulin sensitivity, and shows antioxidant effects.

METHODS

The effects of Rh2 on cell survival, extracellular matrix (ECM) protein expression, and cell differentiation were examined. The antioxidant effects of Rh2 in UV-irradiated normal human dermal fibroblast (NHDF) cells were also examined. The effects of Rh2 on mitochondrial function, morphology, and mitophagy were investigated in UV-irradiated NHDF cells.

RESULTS

Rh2 treatment promoted the proliferation of NHDF cells. Additionally, Rh2 increased the expression levels of ECM proteins and growth-associated immediate-early genes in ultraviolet (UV)-irradiated NHDF cells. Rh2 also affected antioxidant protein expression and increased total antioxidant capacity. Furthermore, treatment with Rh2 ameliorated the changes in mitochondrial morphology, induced the recovery of mitochondrial function, and inhibited the initiation of mitophagy in UV-irradiated NHDF cells.

CONCLUSION

Rh2 inhibits mitophagy and reinstates mitochondrial ATP production and membrane potential in NHDF cells damaged by UV exposure, leading to the recovery of ECM, cell proliferation, and antioxidant capacity.

摘要

背景

除用作健康食品外，人参因其广泛的健康益处还被用于化妆品和洗发水中。人参皂苷Rh2是人参的一种成分，具有抑制肿瘤细胞增殖和分化、促进胰岛素分泌、提高胰岛素敏感性以及抗氧化作用。

方法

研究了Rh2对细胞存活、细胞外基质（ECM）蛋白表达和细胞分化的影响。还检测了Rh2在紫外线照射的正常人皮肤成纤维细胞（NHDF）中的抗氧化作用。在紫外线照射的NHDF细胞中研究了Rh2对线粒体功能、形态和线粒体自噬的影响。

结果

Rh2处理促进了NHDF细胞的增殖。此外，Rh2增加了紫外线（UV）照射的NHDF细胞中ECM蛋白和生长相关即早基因的表达水平。Rh2还影响抗氧化蛋白表达并提高了总抗氧化能力。此外，Rh2处理改善了线粒体形态的变化，诱导了线粒体功能的恢复，并抑制了紫外线照射的NHDF细胞中线粒体自噬的启动。

结论

Rh2抑制紫外线照射损伤的NHDF细胞中的线粒体自噬，恢复线粒体ATP生成和膜电位，从而导致ECM、细胞增殖和抗氧化能力的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/923229a264ea/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/b94596971583/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/9ef93930c15e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/f1e753430ec3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/15156b7551ff/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/be8769b6d8e3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/8b560b452404/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/923229a264ea/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/b94596971583/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/9ef93930c15e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/f1e753430ec3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/15156b7551ff/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/be8769b6d8e3/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/8b560b452404/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9140/9459079/923229a264ea/gr6.jpg

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3
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