Çiçek Fatih, Köle Mehmet Tolga
Department of Pediatric Allergy and Immunology, Kartal Dr. Lütfi Kırdar City Hospital, University of Health Sciences, Istanbul 34870, Turkey.
Department of Pediatrics, Kartal Dr. Lütfi Kırdar City Hospital, University of Health Sciences, Istanbul 34870, Turkey.
Children (Basel). 2023 Sep 7;10(9):1522. doi: 10.3390/children10091522.
Atopic dermatitis (AD) is a chronic and recurrent inflammatory skin condition characterized by itching, eczematous plaques, and dry skin. Despite ongoing research, its exact cause remains elusive. In this study, we aimed to explore the factors that influence the severity of AD in children and assess the relationship between serum vitamin D levels and the disease's severity. We enrolled 96 AD patients in our investigation, evaluated their clinical condition using the Scoring Atopic Dermatitis (SCORAD) index, and compared them to a group of 90 healthy controls. Our analysis revealed that serum vitamin D levels and eosinophil counts significantly impacted the SCORAD index ( < 0.001). According to standardized regression coefficients, for each incremental unit in serum vitamin D levels, the SCORAD index exhibited a decrease of 0.449 units. Similarly, a one-unit increase in eosinophil count resulted in a 0.009 unit increase in the SCORAD index. It is worth noting that the influence of serum vitamin D levels on disease severity surpasses that of eosinophil counts and atopic conditions. In our patient cohort, we uncovered a negative correlation (r = -0.419, < 0.001) between serum vitamin D levels and the SCORAD index. Our findings suggest that low serum vitamin D levels may have a more substantial impact on AD severity than atopic conditions and eosinophilia. Furthermore, we observed a negative association between the severity of AD and serum 25(OH)D3 levels.
特应性皮炎（AD）是一种慢性复发性炎症性皮肤病，其特征为瘙痒、湿疹样斑块和皮肤干燥。尽管研究不断，但确切病因仍不明确。在本研究中，我们旨在探讨影响儿童AD严重程度的因素，并评估血清维生素D水平与疾病严重程度之间的关系。我们招募了96例AD患者进行调查，使用特应性皮炎评分（SCORAD）指数评估他们的临床状况，并与90名健康对照者进行比较。我们的分析表明，血清维生素D水平和嗜酸性粒细胞计数对SCORAD指数有显著影响（<0.001）。根据标准化回归系数，血清维生素D水平每增加一个单位，SCORAD指数下降0.449个单位。同样，嗜酸性粒细胞计数增加一个单位，SCORAD指数增加0.009个单位。值得注意的是，血清维生素D水平对疾病严重程度的影响超过嗜酸性粒细胞计数和特应性状况。在我们的患者队列中，我们发现血清维生素D水平与SCORAD指数之间存在负相关（r = -0.419，<0.001）。我们的研究结果表明，低血清维生素D水平可能比特应性状况和嗜酸性粒细胞增多对AD严重程度的影响更大。此外，我们观察到AD严重程度与血清25(OH)D3水平之间存在负相关。
