Przechowski Kamil, Krawczyk Marta Natalia, Krasowski Rafał, Pawliczak Rafał, Kleniewska Paulina
Department of Immunopathology, Faculty of Medicine, Medical University of Lodz, Żeligowskiego 7/9, 90-752 Łódź, Poland.
Nutrients. 2025 Aug 8;17(16):2582. doi: 10.3390/nu17162582.
Atopic dermatitis (AD), a common chronic inflammatory disease in children and adults, is often studied to find the best way to prevent or reduce its severity. One of the substances tested so far is vitamin D. The main aim of this paper was to determine whether vitamin D truly brings benefits to people with AD or whether its action is too insignificant to have clinical significance. The review covered articles-observational studies, several animal studies and randomized controlled trials (RCTs)-available in the PubMed database and published after 2019. Full-text manuscripts in English were used. Observational studies presented both therapeutic effects of vitamin D and its lack of influence on AD. They also determined that vitamin D receptor (VDR) polymorphism may indeed affect the occurrence and severity of this disease. Similarly, the results of vitamin D's effect on AD are inconclusive in RCTs. Meanwhile, animal studies showed only the attenuation of disease symptoms in mice. The still-growing number of studies on vitamin D and its association with AD, due to many internal and external distorting factors, has not been able to provide us with definitive results. It is necessary to conduct further appropriately designed large-scale studies, including long-term observation.
特应性皮炎（AD）是一种常见于儿童和成人的慢性炎症性疾病，人们经常对其进行研究以寻找预防或减轻其严重程度的最佳方法。迄今为止所测试的物质之一是维生素D。本文的主要目的是确定维生素D是否真的能给AD患者带来益处，或者其作用是否微不足道而没有临床意义。该综述涵盖了2019年后发表在PubMed数据库中的文章——观察性研究、多项动物研究和随机对照试验（RCT）。使用的是英文全文手稿。观察性研究既呈现了维生素D的治疗效果，也表明了其对AD没有影响。它们还确定维生素D受体（VDR）多态性可能确实会影响这种疾病的发生和严重程度。同样，在随机对照试验中，维生素D对AD的影响结果也尚无定论。与此同时，动物研究仅显示了小鼠疾病症状的减轻。由于许多内部和外部的干扰因素，关于维生素D及其与AD关联的研究数量仍在增加，但尚未能够为我们提供明确的结果。有必要进行进一步设计合理的大规模研究，包括长期观察。
