Sharma Saurabh, Kaur Tejinder, Malhotra Suresh Kumar, Rai Jaswant, Chaudhari Sunil
Junior Resident, Department of Dermatology, Venereology and Leprosy, Govt. Medical College, Amritsar, Punjab, India.
Associate Professor, Department of Dermatology, Venereology and Leprosy, Govt. Medical College, Amritsar, Punjab, India.
J Clin Diagn Res. 2017 Jul;11(7):WC01-WC03. doi: 10.7860/JCDR/2017/27188.10223. Epub 2017 Jul 1.
Atopic Dermatitis (AD) is a common chronic inflammatory condition characterized clinically by pruritus and eczematous lesions. An inverse relationship has been suggested between serum 25-hydroxyvitamin D concentration and severity of atopic dermatitis.
We carried out this controlled cross-sectional study to evaluate the association between the serum vitamin D levels and SCORAD index.
For this study, 40 patients with clinical diagnosis of AD based on UK diagnostic criteria were enrolled and 40 patients with minor ailments like superficial bacterial, fungal or viral infections and not suffering from atopic dermatitis were taken as controls. Salient presentations were recorded in a pre-set proforma. Serum 25-hydroxyvitamin D levels were determined through Sandwich-ELISA technique. SCORAD (Scoring AD) index was used to evaluate the severity of the disease.
Mean value of serum 25-hydroxyvitamin D levels in cases was 30.38 nmol/l whereas in controls, it was 53.46 nmol/l. The decrease in serum levels in cases was statistically highly significant (p-value <0.001). Mean±S.D of serum vitamin D levels in mild disease was 33.29±5.89 nmol/l, in moderate disease was 31.52±6.04 nmol/l and in severe form of disease was 21.24±3.17nmol/l. The correlation between SCORAD and serum 25-hydroxyvitamin D levels was also statistically significant.
The data suggests an inverse relationship between serum levels of vitamin D and the SCORAD Index.
特应性皮炎（AD）是一种常见的慢性炎症性疾病，临床特征为瘙痒和湿疹样皮损。血清25-羟基维生素D浓度与特应性皮炎严重程度之间存在负相关关系。
我们开展了这项对照横断面研究，以评估血清维生素D水平与SCORAD指数之间的关联。
本研究纳入了40例根据英国诊断标准临床诊断为AD的患者，并选取了40例患有浅表细菌、真菌或病毒感染等轻微疾病且未患特应性皮炎的患者作为对照。显著表现记录在预设的表格中。通过夹心酶联免疫吸附测定技术测定血清25-羟基维生素D水平。使用SCORAD（特应性皮炎评分）指数评估疾病的严重程度。
病例组血清25-羟基维生素D水平的平均值为30.38 nmol/l，而对照组为53.46 nmol/l。病例组血清水平的降低在统计学上具有高度显著性（p值<0.001）。轻度疾病患者血清维生素D水平的均值±标准差为33.29±5.89 nmol/l，中度疾病患者为31.52±6.04 nmol/l，重度疾病患者为21.24±3.17 nmol/l。SCORAD与血清25-羟基维生素D水平之间的相关性在统计学上也具有显著性。
数据表明维生素D血清水平与SCORAD指数之间存在负相关关系。
