Maes L, Delvaux G, Wu J X
Eur Surg Res. 1987;19(3):185-92. doi: 10.1159/000128699.
An experimental end-to-end anastomosis of the common femoral artery was performed in 45 adult Wistar rats. The vessel wall condition was assessed at 10 min, 3 days, 1, 2, 4, and 8 weeks following surgery by scanning and transmission electron microscopy. The microsurgical procedure inflicts extensive trauma in all layers of the arterial wall, with a desendothelialization largely surpassing the surgical field. Reendothelialization was completed at 2 weeks. Apparently, and as compared to less damaging vessel wall manipulations, such deep medial and wide endothelial lesions do not retard vessel wall healing to normal functionality. Moreover, the formation of primary atherogenic structures by smooth muscle cell migration to the intima seems restricted.
在45只成年Wistar大鼠身上进行了股总动脉的实验性端端吻合术。术后10分钟、3天、1周、2周、4周和8周，通过扫描电子显微镜和透射电子显微镜评估血管壁状况。显微手术操作对动脉壁的所有层都造成了广泛损伤，内皮剥脱范围大大超过手术区域。内皮再形成在2周时完成。显然，与损伤较小的血管壁操作相比，如此严重的中层和广泛的内皮损伤并不会阻碍血管壁恢复到正常功能。此外，平滑肌细胞向内膜迁移形成原发性动脉粥样硬化结构的过程似乎受到限制。
