College of Traditional Chinese medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Research Center for Infectious Diseases, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Immunol. 2022 Aug 25;13:971674. doi: 10.3389/fimmu.2022.971674. eCollection 2022.
Various studies are being conducted on oncolytic virotherapy which one of the mechanisms is mediating interferon (IFN) production by it exerts antitumor effects. The antiviral effect of IFN itself has a negative impact on the inhibition of oncolytic virus or tumor eradication. Therefore, it is very critical to understand the mechanism of IFN regulation by oncolytic viruses, and to define its mechanism is of great significance for improving the antitumor effect of oncolytic viruses. This review focuses on the regulatory mechanisms of IFNs by various oncolytic viruses and their combination therapies. In addition, the exerting and the producing pathways of IFNs are briefly summarized, and some current issues are put forward.
目前正在进行多种溶瘤病毒治疗的研究，其中一种机制是通过介导干扰素（IFN）的产生来发挥抗肿瘤作用。IFN 本身的抗病毒作用对溶瘤病毒的抑制或肿瘤的清除有负面影响。因此，了解溶瘤病毒对 IFN 的调节机制非常关键，明确其机制对于提高溶瘤病毒的抗肿瘤效果具有重要意义。本综述重点介绍了各种溶瘤病毒及其联合治疗对 IFN 的调节机制。此外，还简要总结了 IFN 的作用和产生途径，并提出了一些当前存在的问题。
