营养生物盾牌超级食品粉对免疫系统功能的影响：COVID-19 患者的临床试验研究。
The effects of nutrition bio-shield superfood powder on immune system function: A clinical trial study among patients with COVID-19.
机构信息
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Front Immunol. 2022 Aug 25;13:919402. doi: 10.3389/fimmu.2022.919402. eCollection 2022.
UNLABELLED
The present study aimed to evaluate the effects of Nutrition Bio-shield Superfood (NBS) powder on the immune system function and clinical manifestations in patients with COVID-19. We compare the effects of NBS powder on the immune system function and clinical manifestations among two different groups: 1) intervention group receiving standard treatment scheduled according to treatment guidelines plus NBS powder, and 2) control group receiving only the same standard treatment. The serum levels of IL-2, IL-6, IL-17, IFNγ, and TNFα were determined after four weeks of treatment by specific ELISA kits according to the manufacturer's instructions. Finally, the level of immune system stimulation and inflammatory markers were compared at baseline and after intervention in both groups. Data were analyzed using SPSS (version 22). A p-value of ≤ 0.05 was set as significant. A total of 47 patients with COVID-19 (24 patients in the intervention group and 23 patients in the control group) were included in this study. Results showed that the differences in the mean decrease of IL-2, IL-6, and TNF-α in the intervention group in comparison to the control group were 0.93, 10.28, and 8.11 pg/ml, respectively (P<0.001). On the other hand, there was no difference in IL-17, IFNγ, monocytes, eosinophil, and other inflammatory indices between the intervention and control groups. Although NBS powder was able to significantly decrease the levels of some proinflammatory cytokines in patients with COVID-19, however, it is noteworthy that the course of the disease was to large part unaffected by NBS power and there was a reduction independent of treatment. The present study indicates that NBS powder could provide a beneficial anti-inflammatory effect in patients with COVID-19. Hence, NBS in treating patients with COVID-19 shows promise as an adjuvant to the current standard antiviral treatment of such patients.
CLINICAL TRIAL REGISTRATION
https://www.irct.ir, identifier IRCT20200426047206N1.
目的
本研究旨在评估营养生物盾牌超级食品（NBS）粉对 COVID-19 患者免疫系统功能和临床症状的影响。我们比较了 NBS 粉对两组患者免疫系统功能和临床症状的影响：1）干预组接受根据治疗指南安排的标准治疗加 NBS 粉，2）对照组仅接受相同的标准治疗。根据制造商的说明，通过特定的 ELISA 试剂盒在治疗 4 周后测定血清中 IL-2、IL-6、IL-17、IFNγ 和 TNFα 的水平。最后，比较两组患者在基线和干预后的免疫系统刺激和炎症标志物水平。使用 SPSS（版本 22）进行数据分析。p 值≤0.05 为显著。共纳入 47 例 COVID-19 患者（干预组 24 例，对照组 23 例）。结果表明，与对照组相比，干预组中 IL-2、IL-6 和 TNF-α 的平均下降量分别为 0.93、10.28 和 8.11 pg/ml（P<0.001）。另一方面，干预组和对照组之间的 IL-17、IFNγ、单核细胞、嗜酸性粒细胞和其他炎症指标没有差异。虽然 NBS 粉能显著降低 COVID-19 患者体内某些促炎细胞因子的水平，但值得注意的是，NBS 粉对疾病的进程并没有太大影响，而且这种降低与治疗无关。本研究表明，NBS 粉可能对 COVID-19 患者具有有益的抗炎作用。因此，NBS 在治疗 COVID-19 患者方面显示出作为此类患者当前标准抗病毒治疗的辅助手段的潜力。
临床试验注册
https://www.irct.ir，标识符 IRCT20200426047206N1。
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