Weidmann Maxwell D, Ofori Kenneth, Rai Alex J
Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY.
Am J Clin Pathol. 2021 Feb 11;155(3):333-342. doi: 10.1093/ajcp/aqaa205.
Laboratory testing and the measurement of appropriate biomarkers play a critical role in managing patients with coronavirus disease 2019 (COVID-19), allowing for disease diagnosis, monitoring progression, prognostication, prediction of treatment response, and risk stratification. We sought to characterize these effects on a more detailed, mechanistic level.
We reviewed the literature and identified a multitude of reports that describe the unique effects of this virus and its devastating consequences to multiple organ systems in COVID-19 patients.
There are specific alterations in biomarkers related to coagulation, depopulation of T-cell subtypes, the cytokine storm and inflammation, and kidney and cardiac dysfunction.
Laboratory measurement of specific parameters and the use of appropriate prognostic, predictive, and monitoring biomarkers afford clinicians the ability to make informed medical decisions and guide therapy for patients afflicted with this dreaded disease.
实验室检测及合适生物标志物的测量在管理2019冠状病毒病（COVID-19）患者中起着关键作用，有助于疾病诊断、监测病情进展、预后评估、预测治疗反应及风险分层。我们试图在更详细的机制层面描述这些影响。
我们查阅了文献，发现众多报告描述了这种病毒的独特影响及其对COVID-19患者多个器官系统的破坏性后果。
与凝血、T细胞亚群减少、细胞因子风暴和炎症以及肾脏和心脏功能障碍相关的生物标志物存在特定改变。
特定参数的实验室测量以及合适的预后、预测和监测生物标志物的使用，使临床医生有能力为患有这种可怕疾病的患者做出明智的医疗决策并指导治疗。
