Caporali M G, Popoli P, de Carolis A S
Eur J Pharmacol. 1987 Jun 4;137(2-3):247-9. doi: 10.1016/0014-2999(87)90229-9.
The EEG and behavioral effects of caffeine, carbamazepine and haloperidol were assessed in adult male rabbits. Caffeine (50 mg/kg i.v.) induced a long-lasting EEG desynchronization (45.6/60 min in mean) which was not modified by pretreatment of the rabbits with carbamazepine or haloperidol. All these drugs, administered alone, failed to induce stereotypy in rabbits. The administration of caffeine in combination with carbamazepine and/or haloperidol induced stereotyped behavior.
在成年雄性兔子中评估了咖啡因、卡马西平和氟哌啶醇对脑电图（EEG）及行为的影响。静脉注射咖啡因（50毫克/千克）可诱发持久的脑电图去同步化（平均45.6/60分钟），兔子预先使用卡马西平或氟哌啶醇对此并无影响。单独给予所有这些药物均未能诱发兔子的刻板行为。咖啡因与卡马西平和/或氟哌啶醇联合使用可诱发刻板行为。
