Changchun University of Chinese Medicine, Changchun 130117, China.
Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
J Diabetes Res. 2022 Feb 22;2022:3448618. doi: 10.1155/2022/3448618. eCollection 2022.
The final outcome of diabetes is chronic complications, of which vascular complications are the most serious, which is the main cause of death for diabetic patients and the direct cause of the increase in the cost of diabetes. Type 1 and type 2 diabetes are the main types of diabetes, and their pathogenesis is completely different. Type 1 diabetes is caused by genetics and immunity to destroy a large number of cells, and insulin secretion is absolutely insufficient, which is more prone to microvascular complications. Type 2 diabetes is dominated by insulin resistance, leading to atherosclerosis, which is more likely to progress to macrovascular complications. This article explores the pathogenesis of two types of diabetes, analyzes the pathogenesis of different vascular complications, and tries to explain the different trends in the progression of different types of diabetes to vascular complications, in order to better prevent diabetes and its vascular complications.
糖尿病的最终结果是慢性并发症，其中血管并发症最为严重，这是糖尿病患者死亡的主要原因，也是糖尿病费用增加的直接原因。1 型和 2 型糖尿病是糖尿病的主要类型，其发病机制完全不同。1 型糖尿病是由遗传和免疫引起的，会大量破坏细胞，胰岛素分泌绝对不足，更容易发生微血管并发症。2 型糖尿病以胰岛素抵抗为主，导致动脉粥样硬化，更容易发展为大血管并发症。本文探讨了两种类型糖尿病的发病机制，分析了不同血管并发症的发病机制，并试图解释不同类型糖尿病向血管并发症进展的不同趋势，以期更好地预防糖尿病及其血管并发症。
