Beatriz Vilela Teixeira Ana, Greghi de Carvalho Gabriela, Cândido Dos Reis Andréa
Departament of Dental Materials and Prosthesis, Ribeirão Preto School of Dentistry, University of São Paulo, Av. Do Café, s/n, 14040-904 Ribeirão Preto, SP, Brazil.
Saudi Dent J. 2022 Sep;34(6):411-420. doi: 10.1016/j.sdentj.2022.05.007. Epub 2022 Jun 10.
This review aimed to identify antimicrobial agents incorporated into dental materials obtained through additive manufacturing and their efficacy.
Protocol registration was performed in Open Science Framework (osf.io/sp3xa/) and an electronic search was carried out in the databases PubMed, Science Direct, Embase, Lilacs, and Scopus, up to February 2022, combining the terms ("additive manufacturing" OR "3D printing") AND (antimicrobial). Eligibility criteria included: experimental studies that incorporated 3D printing material with an antimicrobial agent for dental application; that evaluated antimicrobial activity; articles published in peer-reviewed journals and in English.
The database search resulted in 1139 references. The manual selection was carried out in 851 studies. Twenty-five articles were selected for full-text reading, of which 8 were included in this review. Polymers were the dental materials most often modified with antimicrobial agents for 3D printing, followed by metal alloy. The antimicrobials used were mainly nanoparticles, metal particles, antifungals, monomers containing quaternary ammonium salt, and antiseptics such as chlorhexidine.
The addition of the antimicrobial agents in polymers and alloy for additive manufacturing showed promising efficacy against spp., Gram-positive and Gram-negative bacteria.
本综述旨在确定通过增材制造获得的牙科材料中所含的抗菌剂及其功效。
在开放科学框架（osf.io/sp3xa/）中进行方案注册，并在PubMed、Science Direct、Embase、Lilacs和Scopus数据库中进行电子检索，检索截至2022年2月，将术语（“增材制造”或“3D打印”）与（抗菌剂）相结合。纳入标准包括：将3D打印材料与牙科应用抗菌剂结合的实验研究；评估抗菌活性；发表在同行评审期刊且为英文的文章。
数据库检索得到1139篇参考文献。对851项研究进行了人工筛选。选择25篇文章进行全文阅读，其中8篇纳入本综述。聚合物是3D打印中最常添加抗菌剂进行改性的牙科材料，其次是金属合金。使用的抗菌剂主要是纳米颗粒、金属颗粒、抗真菌剂、含季铵盐的单体以及洗必泰等防腐剂。
在用于增材制造的聚合物和合金中添加抗菌剂对特定菌种、革兰氏阳性菌和革兰氏阴性菌显示出有前景的功效。
