Zhang Dejin, Sun Shu, Wu Qi, Xie Yong, Liu Chengcheng, Wang Cong, Zhang Keying, Shi Hongwei, Zhuo Xin, Wang Hongyan
School of Chemistry and Chemical Engineering, Suzhou University, Suzhou 234000, Anhui, China.
School of Biology and Food Engineering, Suzhou University, Suzhou 234000, Anhui, China.
ACS Omega. 2022 Aug 24;7(35):31495-31501. doi: 10.1021/acsomega.2c04176. eCollection 2022 Sep 6.
-Butylphenol is widely used as an intermediate in organic synthesis, and the catalyst for the alkylation reaction of phenol and -butyl alcohol is the key to synthesizing -butylphenol. In our work, a catalyst, 1H-imidazole-1-acetic acid tosilate ([HIMA]OTs), was synthesized and characterized, and an efficient and easily recyclable catalytic system of an ionic liquid was established. In addition, the kinetic and thermodynamic parameters were calculated; the positive value of Δ* indicated the endothermic nature of the alkylation reaction, and the positive value of Δ* and negative value of Δ* implied that the process of alkylation of phenol and -butyl alcohol was spontaneous in the current reaction system. The recovery experiments of [HIMA]OTs were performed, and an excellent recycling performance was obtained. This method provides a potential way for the industrial synthesis of -butylphenol.
叔丁基苯酚被广泛用作有机合成中的中间体，而苯酚与叔丁醇烷基化反应的催化剂是合成叔丁基苯酚的关键。在我们的工作中，合成并表征了一种催化剂对甲苯磺酸1H-咪唑-1-乙酸盐（[HIMA]OTs），并建立了一种高效且易于回收的离子液体催化体系。此外，还计算了动力学和热力学参数；Δ的正值表明烷基化反应是吸热的，而Δ的正值和Δ*的负值意味着在当前反应体系中苯酚与叔丁醇的烷基化过程是自发的。进行了[HIMA]OTs的回收实验，并获得了优异的循环性能。该方法为叔丁基苯酚的工业合成提供了一条潜在途径。
