Fu Liping, Zhang Jinming, Zhou Kaixiang, Zhang Xiaojun, Xie Hengge, Zhu Mingwei, Cui Mengchao, Wang Ruimin
Department of Nuclear Medicine, China-Japan Friendship Hospital, Beijing, China.
Department of Nuclear Medicine, First Medical Center, Chinese PLA General Hospital, Beijing, China.
Front Aging Neurosci. 2022 Aug 26;14:994750. doi: 10.3389/fnagi.2022.994750. eCollection 2022.
To evaluate the effectiveness of a new tracer ()-1-(4-(6-(dimethylamino)quinoxalin-2-yl)phenoxy)-3-fluoropropan-2-ol ([F]-S16), in distinguishing patients with AD from HCs.
Paired [F]-S16 and [F]-THK5317 scans were acquired in five patients with AD, six HCs, one subject with a semantic variant of primary progressive aphasia (sv-PPA) and one subject with probable progressive supranuclear palsy (PSP). Dynamic PET scanning was performed over 90 min after injection of the tracers. Standardized uptake values (SUV) and cortical-to-cerebellum standardized uptake value ratios (SUVRs) were used for tau deposition semi-quantization. A voxel-based analysis was employed to assess the uptake difference between populations.
[F]-S16 exhibited excellent blood-brain-barrier penetration. AD patients showed increased cortical [F]-THK5317 and [F]-S16 binding. Compared to HCs, AD patients showed significantly increased cortical [F]-S16 uptake in the bilateral occipital cortex, posterior cingulated cortex/precuneus, and lateral frontal cortex. Notable [F]-S16 uptake was observed in the basal ganglia and brainstem compared to the neocortex. A substantial [F]-S16 signal was detected in the basal ganglia and midbrain in a patient with probable PSP and in the bilateral anterior temporal cortex in a sv-PPA patient.
[F]-S16 might be of help to detect tau protein .
评估新型示踪剂（）-1-（4-（6-（二甲基氨基）喹喔啉-2-基）苯氧基）-3-氟丙-2-醇（[F]-S16）在区分阿尔茨海默病（AD）患者与健康对照者（HCs）方面的有效性。
对5例AD患者、6例HCs、1例原发性进行性失语语义变异型（sv-PPA）患者和1例可能的进行性核上性麻痹（PSP）患者进行了[F]-S16和[F]-THK5317配对扫描。注射示踪剂后90分钟内进行动态PET扫描。标准化摄取值（SUV）和皮质与小脑标准化摄取值比值（SUVRs）用于tau沉积的半定量分析。采用基于体素的分析方法评估不同人群之间的摄取差异。
[F]-S16表现出优异的血脑屏障穿透性。AD患者皮质[F]-THK5317和[F]-S16结合增加。与HCs相比，AD患者双侧枕叶皮质、后扣带回皮质/楔前叶和外侧额叶皮质的皮质[F]-S16摄取显著增加。与新皮质相比，在基底神经节和脑干观察到显著的[F]-S16摄取。在1例可能的PSP患者的基底神经节和中脑以及1例sv-PPA患者的双侧颞叶前皮质检测到大量[F]-S16信号。
[F]-S16可能有助于检测tau蛋白。
