Skakun N P, Koval'chuk S F
Farmakol Toksikol. 1987 May-Jun;50(3):97-9.
Carbon tetrachloride administered together with ethanol was found in experiments on male albino rats to cause a severe liver damage. The use of unithiol, flakumin, tocopherol acetate, silymarin and silybor and also their combinations under these conditions not only decreases lipid hyperperoxidation and prevents depletion of the reduced glutathione pool but also retains a functional liver disturbance. Silybor, silymarin and tocopherol acetate in combination with flakumin proved to be the most efficient.
在雄性白化病大鼠实验中发现，四氯化碳与乙醇一起使用会导致严重的肝损伤。在这些条件下，使用二巯基丙醇、弗拉库明、维生素E醋酸酯、水飞蓟宾和水飞蓟硼以及它们的组合，不仅能减少脂质过氧化，防止还原型谷胱甘肽池的消耗，还能维持肝脏功能紊乱。事实证明，水飞蓟硼、水飞蓟宾和维生素E醋酸酯与弗拉库明联合使用最为有效。
