Skakun N P, Shman'ko V V
Farmakol Toksikol. 1986 Jul-Aug;49(4):86-9.
In male albino rats tocopherol acetate and sodium selenite were shown to be efficient in treatment of isoniazide-induced liver damage. The disturbances of secretion of bile, bile acids and bilirubin and excretion of cholesterol were less pronounced. A decrease of the activity of marker blood serum enzymes--alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase--also indicated the hepatoprotective effect of these drugs. The intensity of lipoperoxidation indicated by a decrease of lipid peroxidation indices in the liver and blood was diminished. Tocopherol acetate and sodium selenite increase the number of sulfhydryl groups but decrease the number of disulfide groups in these biosubstrates.
在雄性白化病大鼠中，已证明醋酸生育酚和亚硒酸钠在治疗异烟肼诱导的肝损伤方面有效。胆汁、胆汁酸和胆红素分泌以及胆固醇排泄的紊乱不太明显。血清标志物酶——丙氨酸转氨酶、天冬氨酸转氨酶和碱性磷酸酶——活性的降低也表明了这些药物的肝脏保护作用。肝脏和血液中脂质过氧化指数降低所表明的脂质过氧化强度减弱。醋酸生育酚和亚硒酸钠增加了这些生物底物中巯基的数量，但减少了二硫键的数量。
