Wu Jiarui, Wang Meng, Pan Yuanjie, Pang Yipeng, Tang Yanyan, Song Chang, Zhu Jiahui, Zhang Xian, Huang Qingli
Public Experimental Research Center, Xuzhou Medical University Xuzhou City Jiangsu 221004 China
The First Clinical Medical College, Xuzhou Medical University Xuzhou Jiangsu 221004 China.
RSC Adv. 2022 Aug 22;12(37):23786-23795. doi: 10.1039/d2ra03860a.
Design and fabrication of novel multifunctional nanomaterials as novel "theranostic nanoagents"with high efficiency and low side effects is important for cancer treatment. Herein, we synthesized manganese-oxide and palladium nanoparticle-co-decorated polypyrrole/graphene oxide (MnO@Pd@PPy/GO) nanocomposites, which could be used as a novel "theranostic nanoagent" for cancer treatment. Various spectroscopic and microscopic characterizations of the synthesized MnO@Pd@PPy/GO nanocomposites suggest that the nanocomposites are assembled sequentially by graphene oxide, polypyrrole, palladium nanoparticles and manganese-oxide nanoplates. Further research revealed that the nanocomposites had excellent photothermal conversion performance (reached near 50 °C after 10 min of irradiation), pH responsive enzymatic-like catalytic activity and enhanced magnetic resonance imaging (MRI) performance ( = 7.74 mM s at pH 5.0 and glutathione (GSH)). Cell experiments also testified that combined cancer treatment (the viability of cancer cells is 30%) with photothermal therapy (PTT, the viability of cancer cells is 91% only with irradiation) and chemodynamic therapy (CDT, the viability of cancer cells is 74.7% only with nanocomposites) guided by MRI was achieved when the as-prepared nanocomposites were employed as theranostic nanoagents. This work could provide some new ideas for the controllable synthesis and application of multicomponent nanomaterials.
设计和制造具有高效和低副作用的新型多功能纳米材料作为新型“诊疗纳米试剂”对于癌症治疗至关重要。在此，我们合成了锰氧化物和钯纳米颗粒共修饰的聚吡咯/氧化石墨烯（MnO@Pd@PPy/GO）纳米复合材料，其可作为用于癌症治疗的新型“诊疗纳米试剂”。对合成的MnO@Pd@PPy/GO纳米复合材料进行的各种光谱和显微镜表征表明，该纳米复合材料由氧化石墨烯、聚吡咯、钯纳米颗粒和锰氧化物纳米片依次组装而成。进一步的研究表明，该纳米复合材料具有优异的光热转换性能（照射10分钟后温度达到近50°C）、pH响应性类酶催化活性和增强的磁共振成像（MRI）性能（在pH 5.0和谷胱甘肽（GSH）存在下为7.74 mM s）。细胞实验也证明，当将所制备的纳米复合材料用作诊疗纳米试剂时，可实现由MRI引导的光热疗法（PTT，仅照射时癌细胞活力为91%）和化学动力学疗法（CDT，仅使用纳米复合材料时癌细胞活力为74.7%）联合癌症治疗（癌细胞活力为30%）。这项工作可为多组分纳米材料的可控合成和应用提供一些新思路。
