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腹膜炎可诱导持续性非卧床腹膜透析（CAPD）患者巨噬细胞合成1α,25 - 二羟维生素D3 。

Peritonitis induces the synthesis of 1 alpha,25-dihydroxyvitamin D3 in macrophages from CAPD patients.

作者信息

Hayes M E, O'Donoghue D J, Ballardie F W, Mawer E B

出版信息

FEBS Lett. 1987 Aug 17;220(2):307-10. doi: 10.1016/0014-5793(87)80836-0.

DOI:10.1016/0014-5793(87)80836-0
PMID:3609325
Abstract

Metabolism of 25-[3H]hydroxyvitamin D3 was studied in peritoneal macrophages from renal failure patients on continuous ambulatory peritoneal dialysis (CAPD). Cells from 5 out of 8 patients with a history of peritonitis produced significant amounts of a metabolite chromatographically identical to 1 alpha,25(OH)2D3; but none was produced by cells from non-infected patients. The evidence strongly suggests that peritoneal macrophages stimulated by infection can metabolise 25OHD3 to the active vitamin D3 metabolite, 1 alpha,25(OH)2D3, when maintained in short-term primary culture.

摘要

对接受持续性非卧床腹膜透析（CAPD）的肾衰竭患者的腹膜巨噬细胞中25 - [³H]羟基维生素D3的代谢情况进行了研究。8例有腹膜炎病史的患者中，有5例患者的细胞产生了大量色谱行为与1α,25(OH)₂D₃相同的代谢产物；但未感染患者的细胞未产生该代谢产物。有充分证据表明，感染刺激的腹膜巨噬细胞在短期原代培养时能够将25OHD₃代谢为活性维生素D3代谢产物1α,25(OH)₂D₃。

相似文献

1
Peritonitis induces the synthesis of 1 alpha,25-dihydroxyvitamin D3 in macrophages from CAPD patients.腹膜炎可诱导持续性非卧床腹膜透析（CAPD）患者巨噬细胞合成1α,25 - 二羟维生素D3 。
FEBS Lett. 1987 Aug 17;220(2):307-10. doi: 10.1016/0014-5793(87)80836-0.
2
Metabolism of 25-OH-vitamin D3 by peritoneal macrophages from CAPD patients.持续性非卧床腹膜透析患者腹膜巨噬细胞对25-羟基维生素D3的代谢
Kidney Int. 1991 May;39(5):1005-11. doi: 10.1038/ki.1991.127.
3
Regulation of TNF-alpha by 1alpha,25-dihydroxyvitamin D3 in human macrophages from CAPD patients.1α,25 - 二羟维生素D3对持续性非卧床腹膜透析患者人巨噬细胞中肿瘤坏死因子-α的调节作用
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Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1 alpha,25-dihydroxyvitamin D3 after long-term culture.肺泡横纹肌肉瘤患者血液来源的巨噬细胞在短期培养过程中将25-羟基维生素D3代谢为24,25-二羟基维生素D3，在长期培养后代谢为1α,25-二羟基维生素D3。
J Steroid Biochem Mol Biol. 1991 Mar;38(3):301-6. doi: 10.1016/0960-0760(91)90101-a.
5
Enhancement of 24,25-dihydroxyvitamin D levels in patients treated with continuous ambulatory peritoneal dialysis.
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25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages.脂多糖刺激的正常人巨噬细胞对25-羟基维生素D3的代谢
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Enhancement of ionized calcium and 1,25-dihydroxycholecalciferol loss from peritoneal fluid during peritonitis in patients treated with continuous ambulatory peritoneal dialysis.持续非卧床腹膜透析患者发生腹膜炎时，腹膜液中离子钙和1,25-二羟胆钙化醇丢失增加。
Nephron. 1991;59(1):90-5. doi: 10.1159/000186525.
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Diversity in peritoneal macrophage response of CAPD patients to 1,25-dihydroxyvitamin D3.持续性非卧床腹膜透析患者腹膜巨噬细胞对1,25 - 二羟维生素D3反应的多样性
Kidney Int. 1990 May;37(5):1310-5. doi: 10.1038/ki.1990.116.
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Evaluation of vitamin D-binding protein and vitamin D metabolite loss in children on continuous ambulatory peritoneal dialysis.持续性非卧床腹膜透析患儿维生素 D 结合蛋白及维生素 D 代谢产物丢失情况的评估
Bone Miner. 1992 Jun;17(3):389-98. doi: 10.1016/0169-6009(92)90788-f.
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Differential metabolism of 25-hydroxyvitamin D3 by cultured synovial fluid macrophages and fibroblast-like cells from patients with arthritis.来自关节炎患者的培养滑液巨噬细胞和成纤维样细胞对25-羟基维生素D3的差异代谢
Ann Rheum Dis. 1992 Feb;51(2):220-6. doi: 10.1136/ard.51.2.220.

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Antibacterial responses by peritoneal macrophages are enhanced following vitamin D supplementation.
补充维生素D后，腹膜巨噬细胞的抗菌反应增强。
PLoS One. 2014 Dec 30;9(12):e116530. doi: 10.1371/journal.pone.0116530. eCollection 2014.
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Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes.成纤维细胞生长因子 23 抑制人单核细胞中 1,25-二羟维生素 D 的肾外合成。
J Bone Miner Res. 2013 Jan;28(1):46-55. doi: 10.1002/jbmr.1740.
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Synthesis of the active metabolite of vitamin D, 1,25(OH)2D3, by synovial fluid macrophages in arthritic diseases.关节炎疾病中滑液巨噬细胞对维生素D活性代谢物1,25(OH)₂D₃的合成。
Ann Rheum Dis. 1989 Sep;48(9):723-9. doi: 10.1136/ard.48.9.723.
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Ann Rheum Dis. 1992 May;51(5):632-7. doi: 10.1136/ard.51.5.632.
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Differential metabolism of 25-hydroxyvitamin D3 by cultured synovial fluid macrophages and fibroblast-like cells from patients with arthritis.来自关节炎患者的培养滑液巨噬细胞和成纤维样细胞对25-羟基维生素D3的差异代谢
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