Abdullahi Idris Nasir, Issaoui Rabeb, Usman Yahaya
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Medical Sciences, Ahmadu Bello University, PMB 05 Zaria, Nigeria.
Department of Biology, University of Tunis El-Manar, Tunis, Tunisia.
IJID Reg. 2022 May 28;4:17-24. doi: 10.1016/j.ijregi.2022.05.009. eCollection 2022 Sep.
To provide an empirical insight on nasal colonization and urinary tract infection (UTI) among people living with HIV/AIDS (PLWHA) in Nigeria, a quantitative synthesis and systematic review were executed. A comprehensive bibliometric search was conducted for published articles using the keywords 'nasal carriage', 'Urinary , 'nasal MRSA', 'staphylococci-HIV coinfection', 'urinary MRSA' and 'all states of Nigeria'. Eligible studies and the number of subjects (n) were analysed according to the PRISMA criteria. Out of the 79 examined studies, only 6 (n=1181) and 6 (n= 1350) on nasal and urine samples, respectively, were eligible. The pooled prevalence of nasal carriage and UTI of were 29.6% and 6.8%, respectively. However, the pooled nasal MRSA carriage was 13.4%. The pooled prevalence of -carrying among nasal samples was 13.0%. Molecular typing from 3 studies showed MRSA-ST8-t064 and MSSA-ST15-t084 as the predominant genetic lineages. The isolates from both sample types had the highest (>50%) resistance to penicillin, sulfamethoxazole-trimethoprim, erythromycin, and tetracycline. Multi-drug resistance was not significantly higher among isolates from urine than nasal samples (60% versus 40.0% of eligible studies) (= 0.5271). A moderate and high pooled prevalence of genetically diverse MRSA and -carrying were obtained from PLWHA, respectively. These findings emphasize the importance of routine screening for MRSA among PLWHA in Nigeria and other HIV endemic countries.
为了对尼日利亚艾滋病毒/艾滋病感染者（PLWHA）的鼻腔定植和尿路感染（UTI）提供实证见解，进行了定量综合分析和系统评价。使用关键词“鼻腔携带”“尿液”“鼻腔耐甲氧西林金黄色葡萄球菌（MRSA）”“葡萄球菌 - 艾滋病毒合并感染”“尿液MRSA”和“尼日利亚所有州”对已发表文章进行了全面的文献计量检索。根据PRISMA标准对符合条件的研究和受试者数量（n）进行了分析。在79项审查研究中，分别只有6项（n = 1181）关于鼻腔样本和6项（n = 1350）关于尿液样本的研究符合条件。鼻腔定植和UTI的合并患病率分别为29.6%和6.8%。然而，合并的鼻腔MRSA定植率为13.4%。鼻腔样本中携带[具体细菌，原文未明确]的合并患病率为13.0%。3项研究的分子分型显示MRSA-ST8-t064和MSSA-ST15-t084是主要的遗传谱系。两种样本类型的分离株对青霉素、磺胺甲恶唑 - 甲氧苄啶、红霉素和四环素的耐药性最高（>50%）。尿液分离株的多重耐药性在符合条件的研究中并不显著高于鼻腔样本（分别为60%和40.0%）（P = 0.5271）。分别从PLWHA中获得了遗传多样性MRSA和携带[具体细菌，原文未明确]的中等和高合并患病率。这些发现强调了在尼日利亚和其他艾滋病毒流行国家对PLWHA进行MRSA常规筛查的重要性。
