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在慢性酒精中毒背景下,明显因摄入洗手液导致甲醇中毒而引发的五例死亡病例群。

A Cluster of Five Deaths Due to Methanol Toxicity After Apparent Hand Sanitizer Ingestion in the Setting of Chronic Alcoholism.

作者信息

Krebs Nicolas P, Czarnecki Lawrence

出版信息

Acad Forensic Pathol. 2022 Sep;12(3):90-94. doi: 10.1177/19253621221108622. Epub 2022 Jul 11.

DOI:10.1177/19253621221108622
PMID:36093375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9459400/
Abstract

Methanol toxicity and its associated pathologies have been widely studied, however, at the beginning of the COVID-19 pandemic, there was an increase in methanol toxicity due to apparent consumption of contaminated hand sanitizer. We report a cluster of five deaths and one presumed death due to the apparent consumption of hand sanitizer, contaminated with methanol, in the setting of chronic alcoholism. The deaths occurred in Coconino County, Arizona, over a four-and-a-half-month period (June-October 2020), before and during a Food and Drug Administration recall of contaminated hand sanitizer. Methanol-related deaths are relatively uncommon in Coconino County, with only one methanol associated death (source of ingestion unknown) occurring over the previous five years.

摘要

甲醇毒性及其相关病理已得到广泛研究,然而,在新冠疫情初期,由于明显摄入受污染的洗手液,甲醇中毒事件有所增加。我们报告了一组病例,在慢性酒精中毒的情况下,因明显摄入受甲醇污染的洗手液导致五人死亡,一人疑似死亡。这些死亡事件发生在亚利桑那州科科尼诺县,历时四个半月(2020年6月至10月),正值美国食品药品监督管理局召回受污染洗手液之前及期间。在科科尼诺县,与甲醇相关的死亡相对罕见,在过去五年中仅发生过一例与甲醇相关的死亡(摄入来源不明)。

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本文引用的文献

1
A Geographically Distinct Case of Fatal Methanol Toxicity from Ingestion of a Contaminated Hand Sanitizer Product During the COVID-19 Pandemic.在 COVID-19 大流行期间,因饮用受污染的手部消毒剂产品而导致的具有地域差异的致命甲醇中毒病例。
J Med Toxicol. 2021 Apr;17(2):218-221. doi: 10.1007/s13181-021-00824-9. Epub 2021 Feb 2.
2
Tainted Hand Sanitizer Leads to Outbreak of Methanol Toxicity During SARS-CoV-2 Pandemic.受污染的洗手液导致新冠疫情期间甲醇中毒事件爆发。
Ann Emerg Med. 2021 Jan;77(1):131-132. doi: 10.1016/j.annemergmed.2020.07.011. Epub 2020 Jul 8.
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Marked Escalation in Journal Submissions During COVID-19 Pandemic.新冠疫情期间期刊投稿量显著增加。
Ann Emerg Med. 2021 Jan;77(1):130-131. doi: 10.1016/j.annemergmed.2020.07.003. Epub 2020 Jul 2.
4
Serious Adverse Health Events, Including Death, Associated with Ingesting Alcohol-Based Hand Sanitizers Containing Methanol - Arizona and New Mexico, May-June 2020.与摄入含甲醇的酒精基洗手液相关的严重不良健康事件,包括死亡 - 亚利桑那州和新墨西哥州,2020 年 5 月至 6 月。
MMWR Morb Mortal Wkly Rep. 2020 Aug 14;69(32):1070-1073. doi: 10.15585/mmwr.mm6932e1.
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Methanol as an Unlisted Ingredient in Supposedly Alcohol-Based Hand Rub Can Pose Serious Health Risk.甲醇作为所谓的含酒精洗手液中未列出的成分,可能会带来严重的健康风险。
Int J Environ Res Public Health. 2018 Jul 9;15(7):1440. doi: 10.3390/ijerph15071440.
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N Engl J Med. 2001 Feb 8;344(6):424-9. doi: 10.1056/NEJM200102083440605.
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Methanol poisoning.甲醇中毒
J Emerg Med. 1983;1(1):51-8. doi: 10.1016/0736-4679(83)90009-4.
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The toxicity of methanol.甲醇的毒性。
Life Sci. 1991;48(11):1031-41. doi: 10.1016/0024-3205(91)90504-5.