Corcoran Justin, Feldman Ryan, Theobald Jillian
Medical College of WI, Milwaukee, WI, USA.
Wisconsin Poison Center, Milwaukee, WI, USA.
Clin Toxicol (Phila). 2023 Aug;61(8):613-615. doi: 10.1080/15563650.2023.2255378. Epub 2023 Oct 10.
In July 2020, an outbreak of methanol-contaminated hand sanitizers in the United States prompted our regional poison center to implement a more conservative triage guideline for hand sanitizer exposures. All pediatric hand sanitizer ingestions of more than a "taste" were referred to a healthcare facility for assessment. We then evaluated the effect of this change on identifying patients with methanol poisoning.
This was a single-center, retrospective review of pediatric (<19 years) hand sanitizer ingestions reported to our poison center from May 1, 2020 through January 28, 2022. Methanol and ethanol concentrations were collected if available.
During the study period, we received 801 calls regarding hand sanitizer exposure, of which 140 children were referred to a healthcare facility for hand sanitizer ingestions. Of those, 88 (63%) had methanol and/or ethanol concentrations measured. No child had a detectable methanol concentration, 78 had ethanol testing, and 12 had a detectable ethanol concentration.
In this sample, no patient tested had a detectable methanol concentration. Children who consumed enough to have a detectable ethanol concentration were symptomatic or had an intentional ingestion. Asymptomatic children with unintentional ingestion of hand sanitizer were at low risk for methanol toxicity.
2020年7月，美国爆发了甲醇污染洗手液事件，促使我们地区的中毒控制中心针对洗手液暴露实施了更为保守的分诊指南。所有摄入洗手液量超过“尝一口”的儿童均被转诊至医疗机构进行评估。然后，我们评估了这一变化对识别甲醇中毒患者的影响。
这是一项单中心回顾性研究，对2020年5月1日至2022年1月28日期间向我们中毒控制中心报告的儿科（<19岁）洗手液摄入情况进行了回顾。如有可用数据，收集甲醇和乙醇浓度。
在研究期间，我们接到了801个关于洗手液暴露的电话，其中140名儿童因摄入洗手液被转诊至医疗机构。其中，88名（63%）检测了甲醇和/或乙醇浓度。没有儿童检测到可检测到的甲醇浓度，78名儿童进行了乙醇检测，12名儿童检测到可检测到的乙醇浓度。
在这个样本中，没有检测到患者有可检测到的甲醇浓度。摄入足够量洗手液且检测到可检测到的乙醇浓度的儿童有症状或有故意摄入行为。无症状且无意摄入洗手液的儿童甲醇中毒风险较低。
