Inaba Takako, Fukumura Yuki, Saito Tsuyoshi, Yokoyama Junkichi, Ohba Shinichi, Arakawa Atsushi, Yao Takashi
Division of Diagnostic Pathology, Juntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Human Pathology, Juntendo University School of Medicine, 1-1-19 Motomachi Bldg. 3F, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Case Rep Pathol. 2015;2015:656107. doi: 10.1155/2015/656107. Epub 2015 Mar 1.
Mammary analogue secretory carcinoma (MASC) is a recently recognized tumor of salivary glands characterized by the ETV6-NTRK3 fusion gene. This tumor is very rare in children and adolescents. We report a case of MASC in a 15-year-old girl, the fifth youngest case so far reported. The patient complained of a left infra-auricular mass that gradually enlarged for a year. Fine-needle aspiration cytology/imprint cytology showed individual tumor cells that had faintly eosinophilic granular cytoplasm with secretion granules sometimes seen adjacent to the tumor cells. These cytological features overlapped between those of zymogen granule-poor acinic cell carcinoma (AciCC) and MASC. In addition to the case report, we present a review of the related literature with a focus on the cytological features of MASC. The differential diagnostic clues are also discussed.
乳腺样分泌性癌（MASC）是一种最近才被认识的涎腺肿瘤，其特征为ETV6-NTRK3融合基因。这种肿瘤在儿童和青少年中非常罕见。我们报告一例15岁女孩的MASC病例，这是迄今为止报告的年龄第五小的病例。患者主诉左耳下肿物，逐渐增大一年。细针穿刺细胞学/印片细胞学显示单个肿瘤细胞，其细胞质呈淡嗜酸性颗粒状，有时在肿瘤细胞旁可见分泌颗粒。这些细胞学特征在低酶原颗粒腺泡细胞癌（AciCC）和MASC之间有重叠。除了病例报告外，我们还对相关文献进行了综述，重点关注MASC的细胞学特征。同时也讨论了鉴别诊断线索。
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