Inuggi Alberto, Marenco Giacomo, Bode Juxhin, Bovio Anna, Versaggi Silvio, Favilla Luca, Pereira da Silva Beatriz, Picci Rocco Luigi, Amore Mario, Serafini Gianluca, Escelsior Andrea
IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa, Largo Paolo Daneo 3, 16132, Genoa, Italy.
Eur Arch Psychiatry Clin Neurosci. 2024 Dec 31. doi: 10.1007/s00406-024-01952-3.
Recent studies suggested that structural changes in the cerebellum are implicated in the pathophysiology of bipolar disorder (BD). Here, we aimed to characterize the structural alterations of cerebellar lobules in BD, evaluating their possible relation with those occurring in the rest of the brain. One-hundred-fifty-five type I BD patients were recruited and compared with one-hundred-nineteen controls subjects. Cerebral cortical thickness (CT) was evaluated vertex-wise, while cerebellar CT at the level of its twelve lobules. A widespread pattern of cortical thinning was found in several clusters of BD patients. In the cerebellum, we found an anterior thinning (lobule I_II, III, X) and a posterior thickening (crus I, crus II, lobule VI and lobule IX) of its lobules in BD. Exploring the relation between cerebral and cerebellar CT changes in BD patients, after correcting for age and disease duration, the CT of a large subset of cerebral regions, found thinned in BD, were also inversely correlated with the thickening of cerebellar lobule IX. We speculate that this lobule may undergo adaptive changes to compensate the widespread cortical thinning which characterizes BD syndrome. Such a compensatory adaptation of the cerebellum would be similar to that found in other neurological and psychiatric disorders.
最近的研究表明，小脑的结构变化与双相情感障碍（BD）的病理生理学有关。在此，我们旨在描述BD患者小脑小叶的结构改变，评估它们与大脑其他部位发生的改变之间的可能关系。招募了155名I型BD患者，并与119名对照受试者进行比较。对大脑皮质厚度（CT）进行逐顶点评估，同时对小脑12个小叶水平的CT进行评估。在BD患者的几个簇中发现了广泛的皮质变薄模式。在小脑中，我们发现BD患者的小叶存在前部变薄（小叶I_II、III、X）和后部增厚（脚I、脚II、小叶VI和小叶IX）。在对年龄和病程进行校正后，探索BD患者大脑和小脑CT变化之间的关系，发现BD中变薄的大部分大脑区域的CT也与小脑小叶IX的增厚呈负相关。我们推测，该小叶可能会发生适应性变化，以补偿BD综合征所特有的广泛皮质变薄。小脑的这种代偿性适应与在其他神经和精神疾病中发现的情况类似。
