Zhang Meng, Huang Xiang, Li Boyi, Shang Huifang, Yang Jing
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2022 Jun 6;13:889714. doi: 10.3389/fneur.2022.889714. eCollection 2022.
Neuroimaging studies have shown gray matter structural and functional alterations in patients with idiopathic blepharospasm (iBSP) but with variations. Here we aimed to investigate the specific and common neurostructural/functional abnormalities in patients with iBSP.
A systematic literature search from PubMed, Web of Science and Embase was conducted to identify relevant publications. We conducted separate meta-analysis for whole-brain voxel-based morphometry (VBM) studies and for functional imaging studies, and a multimodal meta-analysis across VBM and functional studies in iBSP, using anisotropic effect size-based signed differential mapping.
The structural database comprised 129 patients with iBSP and 144 healthy controls whilst the functional database included 183 patients with iBSP and 253 healthy controls. The meta-analysis of VBM studies showed increased gray matter in bilateral precentral and postcentral gyri, right supplementary motor area and bilateral paracentral lobules, while decreased gray matter in right superior and inferior parietal gyri, left inferior parietal gyrus, left inferior temporal gyrus, left fusiform gyrus and parahippocampal gyrus. The meta-analysis of functional studies revealed hyperactivity in right dorsolateral superior frontal gyrus, left thalamus and right fusiform gyrus, while hypoactivity in left temporal pole, left insula, left precentral gyrus, bilateral precuneus and paracentral lobules, right supplementary motor area and middle frontal gyrus. The multimodal meta-analysis identified conjoint anatomic and functional changes in left precentral gyrus, bilateral supplementary motor areas and paracentral lobules, right inferior occipital gyrus and fusiform gyrus.
The patterns of conjoint and dissociated gray matter alterations identified in the meta-analysis may enhance our understanding of the pathophysiological mechanisms underlying iBSP.
神经影像学研究已显示特发性眼睑痉挛（iBSP）患者存在灰质结构和功能改变，但存在差异。在此，我们旨在研究iBSP患者特定和常见的神经结构/功能异常。
对PubMed、Web of Science和Embase进行系统文献检索以识别相关出版物。我们分别对基于体素的全脑形态测量（VBM）研究和功能成像研究进行荟萃分析，并使用基于各向异性效应大小的符号差异映射对iBSP中的VBM和功能研究进行多模态荟萃分析。
结构数据库包括129例iBSP患者和144例健康对照，而功能数据库包括183例iBSP患者和253例健康对照。VBM研究的荟萃分析显示双侧中央前回和中央后回、右侧辅助运动区和双侧中央旁小叶灰质增加，而右侧顶上回和顶下回、左侧顶下小叶、左侧颞下回、左侧梭状回和海马旁回灰质减少。功能研究的荟萃分析显示右侧背外侧额上回、左侧丘脑和右侧梭状回活动亢进，而左侧颞极、左侧岛叶、左侧中央前回、双侧楔前叶和中央旁小叶、右侧辅助运动区和额中回活动减退。多模态荟萃分析确定了左侧中央前回、双侧辅助运动区和中央旁小叶、右侧枕下回和梭状回的联合解剖和功能变化。
荟萃分析中确定的联合和分离的灰质改变模式可能会增强我们对iBSP潜在病理生理机制的理解。
