Moreau Aurélie, Pretet Valentin, Paquet Emilie, Giraudet Anne Laure, Kryza David
From the Centre Léon Bérard.
Clin Nucl Med. 2023 Mar 1;48(3):261-263. doi: 10.1097/RLU.0000000000004408. Epub 2022 Sep 12.
We reported the case of a 73-year-old man for whom a prostatic adenocarcinoma with synchronous bone metastases was diagnosed. Because his disease was progressing despite several lines of chemotherapy and hormonotherapy, he was screened with a 68 Ga-PSMA PET/CT for a possible 177 Lu-PSMA-617 therapy. The examination demonstrated an intense diffuse bone uptake related to the known bone involvement. It also showed an unexpected diffuse and intense lung uptake, secondary to an active polyangiitis granulomata. This intense lung uptake prohibits the radioligand therapy.
我们报告了一例73岁男性病例，其被诊断为患有同步骨转移的前列腺腺癌。尽管接受了多线化疗和激素治疗，他的病情仍在进展，因此对其进行了68 Ga-PSMA PET/CT筛查，以评估是否适合进行177 Lu-PSMA-617治疗。检查显示与已知的骨转移相关的强烈弥漫性骨摄取。此外，还意外发现了由于活动性多血管炎肉芽肿继发的弥漫性强烈肺部摄取。这种强烈的肺部摄取使得放射性配体治疗无法进行。
