Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, China.
Nat Prod Res. 2023 Jun;37(11):1787-1796. doi: 10.1080/14786419.2022.2120874. Epub 2022 Sep 12.
Four new norceanothane-type triterpenes, cyclopalin (), and sixteen known compounds () were obtained from the fruits of . Their structures were determined by spectroscopic data, experimental electronic circular dichroism (ECD) and X-ray single crystal analyses. All isolated compounds were assayed for their anti-HIV-1 activity. Compound exhibited potent anti-HIV-1 activity with an EC value of 1.32 μM (SI = 151.52).
从八角茴香的果实中分离得到了四个新的 norceanothane 型三萜类化合物（）和十六个已知化合物（）。通过光谱数据分析、实验电子圆二色性（ECD）和 X 射线单晶分析确定了它们的结构。所有分离得到的化合物均进行了抗 HIV-1 活性测试。化合物 表现出较强的抗 HIV-1 活性，EC 值为 1.32 μM（SI = 151.52）。
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