Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA.
J Aerosol Med Pulm Drug Deliv. 2022 Oct;35(5):286-290. doi: 10.1089/jamp.2022.29069.wdb. Epub 2022 Sep 12.
Experiments designed to image deposition of radiolabel-drug mixtures are useful for estimating inhaled drug delivery and for assessing bioequivalence of delivery devices. Validation of the radiolabel-drug mixture is vital to ensure that subsequent imaging is reflective of drug deposition. Application of gamma attenuation corrections allows both total and regional lung deposition of drug to be estimated by two-dimensional (2D) imaging. Imaging methods are also useful for measuring mucociliary clearance (MC) function. Such measures allow assessment of the efficacy of drugs designed to improve clearance of airway secretions in airway disease. MC rates can be measured by controlled inhalation and gamma camera monitoring of radiolabeled aerosols containing non-permeating tracers. While MC rates reflect the function of the mucociliary apparatus, they are also dependent on regional deposition patterns of the inhaled aerosol.
用于对放射性标记药物混合物沉积进行成像的实验对于估计吸入药物的输送和评估输送装置的生物等效性是有用的。放射性标记药物混合物的验证对于确保随后的成像反映药物沉积是至关重要的。伽马衰减校正的应用允许通过二维（2D）成像来估计药物的总沉积和区域沉积。成像方法也可用于测量黏液纤毛清除（MC）功能。这些措施可用于评估旨在改善气道疾病中气道分泌物清除的药物的疗效。MC 率可以通过受控吸入和包含不可渗透示踪剂的放射性气溶胶的伽马相机监测来测量。虽然 MC 率反映了黏液纤毛装置的功能，但它们也依赖于吸入气溶胶的区域沉积模式。
