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肺黏液清除功能的检测：当前的挑战与未来方向。

detection of pulmonary mucociliary clearance: present challenges and future directions.

机构信息

Center for Regenerative Medicine, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA.

College of Medicine, The Ohio State University, Columbus, OH, USA.

出版信息

Eur Respir Rev. 2024 Sep 18;33(173). doi: 10.1183/16000617.0073-2024. Print 2024 Jul.

DOI:10.1183/16000617.0073-2024
PMID:39293852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11409054/
Abstract

Pulmonary mucociliary clearance (MCC) is an important defence mechanism of the respiratory system and clears pathogens and foreign particles from the airways. Understanding the effect of disease states, drugs, toxins and airway manipulations on MCC could be beneficial in preventing early pulmonary disease and developing new pulmonary therapeutics. This review summarises the current methods and future efforts to detect pulmonary MCC .

摘要

肺部黏液纤毛清除（MCC）是呼吸系统的重要防御机制，可清除气道中的病原体和外来颗粒。了解疾病状态、药物、毒素和气道操作对 MCC 的影响，有助于预防早期肺部疾病和开发新的肺部治疗方法。本文总结了目前检测肺部 MCC 的方法和未来的努力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d7/11409054/c211ff29dbdc/ERR-0073-2024.02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d7/11409054/d3b42096de02/ERR-0073-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d7/11409054/c211ff29dbdc/ERR-0073-2024.02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d7/11409054/d3b42096de02/ERR-0073-2024.01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d7/11409054/c211ff29dbdc/ERR-0073-2024.02.jpg

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JAMA Netw Open. 2023 Dec 1;6(12):e2346598. doi: 10.1001/jamanetworkopen.2023.46598.
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Glutathione and bicarbonate nanoparticles improve mucociliary transport in cystic fibrosis epithelia.谷胱甘肽和碳酸氢盐纳米颗粒可改善囊性纤维化上皮的黏液纤毛转运。
Int Forum Allergy Rhinol. 2024 Jun;14(6):1026-1035. doi: 10.1002/alr.23301. Epub 2023 Nov 17.
3
Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa.
通过肺气道黏膜的气溶胶颗粒传输的计算流体动力学建模
Comput Chem Eng. 2023 Nov;179. doi: 10.1016/j.compchemeng.2023.108458. Epub 2023 Oct 16.
4
The impact of air pollution on respiratory diseases in an era of climate change: A review of the current evidence.空气污染对气候变化时代呼吸系统疾病的影响：当前证据综述。
Sci Total Environ. 2023 Nov 10;898:166340. doi: 10.1016/j.scitotenv.2023.166340. Epub 2023 Aug 15.
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Measuring Anatomical Distributions of Ventilation and Aerosol Deposition with PET-CT.使用 PET-CT 测量通气和气溶胶沉积的解剖分布。
J Aerosol Med Pulm Drug Deliv. 2023 Aug;36(4):210-227. doi: 10.1089/jamp.2023.29086.jgv.
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Nebulised hypertonic saline for cystic fibrosis.雾化高渗盐水治疗囊性纤维化。
Cochrane Database Syst Rev. 2023 Jun 14;6(6):CD001506. doi: 10.1002/14651858.CD001506.pub5.
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The Use of Single Photon Emission Computed Tomography in Aerosol Medicine.单光子发射计算机断层扫描在气溶胶医学中的应用。
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Design of Deposition and Clearance Experiments.沉积和清除实验设计。
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