Faramarzi A, Sharini H, Shanbehzadeh M, Pour M Yousef, Fooladi M, Jalalvandi M, Amiri Sh, Kazemi-Arpanahi H
Department of Biomedical Engineering, Faculty of Medicine, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran.
Department of Health Information Technology, Faculty of Paramedical, Ilam University of Medical Sciences, Ilam, Iran.
Psychiatry Res Neuroimaging. 2022 Oct;326:111532. doi: 10.1016/j.pscychresns.2022.111532. Epub 2022 Aug 28.
This study aimed to investigate the effect of music stimulation on the brain functional mechanism of depressed patients with anhedonia symptoms using functional magnetic resonance imaging (fMRI).
Participants in this study included 20 healthy subjects as the control group, 25 subjects with depression and no anhedonia as the intervention group A, and 24 subjects with depression and anhedonia as the intervention group B. The safely emotional stimulation was done by Iranian music. To investigate the effect of music therapy on the brain, a task including 50 tracks of 12 s Iranian music (traditional and pop) was used. Finally, the data were analyzed using SPM Toolbox in MATLAB software.
The results showed that brain patterns in depressed patients with and without anhedonia could be distinguished based on positive and negative musical stimuli (p < 0.05). Important fMRI biomarker such as effective connectivity strength related to the fronto-limbic network, including the supragenual ACC, subgenual ACC, AMYG, and FFG were evaluated in depressed patients with anhedonia.
This was the first study to investigate the neural circuits involved in music-related emotional processing in patients with anhedonia symptoms. These findings could help advance neurological understandings of anhedonia and suggest new treatments.
本研究旨在使用功能磁共振成像（fMRI）研究音乐刺激对伴有快感缺失症状的抑郁症患者大脑功能机制的影响。
本研究的参与者包括20名健康受试者作为对照组，25名无快感缺失症状的抑郁症患者作为干预组A，以及24名伴有快感缺失症状的抑郁症患者作为干预组B。通过伊朗音乐进行安全的情感刺激。为了研究音乐疗法对大脑的影响，使用了一项包含50首时长12秒的伊朗音乐（传统音乐和流行音乐）的任务。最后，使用MATLAB软件中的SPM Toolbox对数据进行分析。
结果表明，根据正负音乐刺激可以区分有无快感缺失症状的抑郁症患者的脑模式（p < 0.05）。在伴有快感缺失症状的抑郁症患者中，评估了重要的功能磁共振成像生物标志物，如与额-边缘网络相关的有效连接强度，包括膝上前扣带回、膝下前扣带回、杏仁核和梭状回。
这是第一项研究伴有快感缺失症状患者中与音乐相关的情感加工所涉及神经回路的研究。这些发现有助于推进对快感缺失的神经学理解并提出新的治疗方法。
