Banerjee Anirban, Ward Valerie
Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
Department of Chemical Engineering, University of Waterloo, 200 University Avenue West, Waterloo, Ontario N2L 3G1, Canada.
Curr Opin Biotechnol. 2022 Dec;78:102784. doi: 10.1016/j.copbio.2022.102784. Epub 2022 Sep 9.
Microalgae is emerging as a promising platform for the production of recombinant proteins of therapeutic importance. Since microalgae are safe for oral consumption and some microalgal species can form extracellular vesicles, they can potentially be used as edible vaccines or drug-delivery vehicles in addition to their status as naturally rich sources of nutraceutical bioproducts. This article focuses on recent advances in the field of recombinant protein production in microalgae, and developments toward the use of microalgae as a vehicle for drug delivery.
微藻正成为生产具有治疗重要性的重组蛋白的一个有前景的平台。由于微藻可供口服且安全，并且一些微藻物种能够形成细胞外囊泡，因此除了作为天然富含营养生物制品的来源外，它们还具有作为可食用疫苗或药物递送载体的潜力。本文重点介绍微藻重组蛋白生产领域的最新进展，以及微藻作为药物递送载体的发展情况。
