Department of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, MS, USA.
Department of Health, Exercise Science, and Recreation Management. Kevser Ermin Applied Physiology Laboratory, The University of Mississippi, MS, USA.
Neurosci Biobehav Rev. 2022 Oct;141:104858. doi: 10.1016/j.neubiorev.2022.104858. Epub 2022 Sep 9.
It is well-established that a single bout of exercise can reduce pain sensitivity (i.e., exercise-induced hypoalgesia) in healthy individuals. However, exercise-induced hypoalgesia is often impaired in individuals with chronic pain. This might suggest that repeated bouts of exercise (i.e., exercise training) are needed in order to induce a reduction in pain sensitivity (i.e., training-induced hypoalgesia) among individuals with chronic pain, given that a single bout of exercise seems to be insufficient to alter pain. However, the effect of repeated bouts of exercise on pain sensitivity and its underlying mechanisms remain poorly understood. Therefore, the purpose of this review was to provide an overview of the existing literature on training-induced hypoalgesia, as well as discuss potential mechanisms of training-induced hypoalgesia and offer considerations for future research. Existing literature suggests that training interventions may induce hypoalgesic adaptations potentially driven by central nervous system and immune system factors. However, the limited number of randomized controlled trials available, along with the lack of understanding of underlying mechanisms, provides a rationale for future research.
众所周知，单次运动即可降低健康个体的疼痛敏感性（即运动诱导性镇痛）。然而，慢性疼痛患者的运动诱导性镇痛常常受损。这可能表明，为了在慢性疼痛患者中诱导疼痛敏感性降低（即训练诱导性镇痛），需要重复进行多次运动（即运动训练），因为单次运动似乎不足以改变疼痛。然而，重复运动对疼痛敏感性及其潜在机制的影响仍知之甚少。因此，本综述的目的是提供关于训练诱导性镇痛的现有文献综述，并讨论训练诱导性镇痛的潜在机制，并为未来的研究提供考虑。现有文献表明，训练干预可能会引起潜在的镇痛适应，这可能是由中枢神经系统和免疫系统因素驱动的。然而，现有的随机对照试验数量有限，并且对潜在机制的理解不足，这为未来的研究提供了依据。
