Poitras P, Trudel L
Gastroenterol Clin Biol. 1987;11(3 Pt 2):62B-64B.
To evaluate the role of endogenous opiates in the regulation of plasma motilin and the interdigestive motor complex of the small bowel, naloxone was administered in dogs. During the infusion of the opiate antagonist, the frequency of motilin cyclic release and of the motor complex was decreased. Moreover, with naloxone, peak increases in plasma motilin were similar to those measured during the control period in 5 of the 8 experiments. They were lower in 3 occasions. These results suggest that endogenous opiates do not play an essential role in the basal organization of intestinal interdigestive motility but that they are able to modify the frequency and the amplitude of motilin cyclic release. They support the possibility that endogenous opiates could, in some circumstances, exert a significant influence on the motor activity of the small intestine.
为了评估内源性阿片类物质在调节血浆胃动素和小肠消化间期运动复合波中的作用，对犬给予纳洛酮。在注入阿片类拮抗剂期间，胃动素周期性释放的频率和运动复合波的频率降低。此外，在8个实验中的5个实验中，使用纳洛酮时血浆胃动素的峰值升高与对照期测得的峰值相似。在3种情况下较低。这些结果表明，内源性阿片类物质在肠道消化间期运动的基础组织中不发挥重要作用，但它们能够改变胃动素周期性释放的频率和幅度。它们支持内源性阿片类物质在某些情况下可能对小肠运动活动产生重大影响的可能性。
