Itoh Z, Honda R, Hiwatashi K, Takeuchi S, Aizawa I, Takayanagi R, Couch E F
Scand J Gastroenterol Suppl. 1976;39:93-110.
Gastrointestinal contractile activity from the lower esophageal sphincter to the terminal ileum in the conscious dogs was continuously recorded on a multi-channel polygraph for several weeks by means of chronically implanted strain gage force transducers. It was found that the 24-hour gastrointestinal motor activity consisted of the two different major patterns; the digestive and interdigestive patterns. The interdigestive motor activity was characterized by a cyclic recurring, caudad-moving band of strong contractions interrupted by long lasting motor quiescence. When one band of strong contractions reached the distal ileum, another developed in the LES, stomach and duodenum again and propagated in a caudad-direction. Such recycling episodes repeatedly occurred until the next meal. After ingestion of food, gastrointestinal motor activity was continous and such characteristic interdigestive patterns were not observed. Synthetic motilin, 0.1-2.7 mug/kg/hr, was assayed for its motor stimulating activity in the both states. In the digestive state, an i.v. infusion of motlin had no influence upon the motor activity even if the dose was increased up to 6.0 mug/kg/hr. On the other hand, when motilin was infused during the interdigestive state, it induced a pattern precisely like the naturally-occurring interdigestive contractions. Not only the naturally-occurring contractions but also motilin-induced contractions were strongly inhibited by the ingestion of food or an i.v. infusion of pentagastrin (0.2-1.8 mug/kg/hr). Duodenal acidification (0.1 N HC1, 3-16 ml/kg/hr) in the interdigestive state disturbed or inhibited the regular cycle of the natural contractions but was counteracted by exogenous i.v. infusion of motilin. These findings strongly suggest the view that the interdigestive gastrointestinal motor activity is at least in part regulated by circulating motilin concentration in the blood, however, its cyclic recurring, caudad propagating mechanism may be controlled in part by the nervous system. Motilin is the only substance known to be active during the interdigestive state and therefore may be called the interdigestive hormone.
通过长期植入的应变片力传感器，在多通道记录仪上连续数周记录清醒犬从食管下括约肌到回肠末端的胃肠收缩活动。发现24小时胃肠运动活动由两种不同的主要模式组成：消化期和消化间期模式。消化间期运动活动的特征是有一个周期性反复出现、向尾端移动的强烈收缩带，其间有长时间的运动静止期。当一组强烈收缩到达回肠末端时，另一组又在食管下括约肌、胃和十二指肠再次出现并向尾端传播。这种循环发作反复发生，直到下一餐进食。进食后，胃肠运动活动持续存在，未观察到这种典型的消化间期模式。测定了0.1 - 2.7微克/千克/小时的合成胃动素在两种状态下的运动刺激活性。在消化期，静脉输注胃动素即使剂量增加到6.0微克/千克/小时，对运动活动也没有影响。另一方面，在消化间期输注胃动素时，它会诱发一种与自然发生的消化间期收缩完全相同的模式。自然发生的收缩以及胃动素诱发的收缩都受到进食或静脉输注五肽胃泌素（0.2 - 1.8微克/千克/小时）的强烈抑制。消化间期十二指肠酸化（0.1N盐酸，3 - 16毫升/千克/小时）会干扰或抑制自然收缩的正常周期，但可被静脉输注外源性胃动素抵消。这些发现有力地表明，消化间期胃肠运动活动至少部分受血液中循环胃动素浓度调节，然而，其周期性反复、向尾端传播的机制可能部分受神经系统控制。胃动素是已知在消化间期有活性的唯一物质，因此可称为消化间期激素。
