人类宿主寻找蚊子中的化学感觉离子型受体。
Chemosensory ionotropic receptors in human host-seeking mosquitoes.
机构信息
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Curr Opin Insect Sci. 2022 Dec;54:100967. doi: 10.1016/j.cois.2022.100967. Epub 2022 Sep 10.
Half the world's human population is at risk for mosquito-borne diseases. Mosquitoes rely mainly on their sense of smell to find a vertebrate blood host, nectar source, and a suitable oviposition site. Advances in neurogenetic tools have now aided our understanding of the receptors that mediate the detection of sensory cues that emanate from humans. Recent studies in the anthropophilic mosquito vectors, Aedes aegypti and Anopheles gambiae, have implicated the chemosensory ionotropic-receptor (IR) family in the detection of behaviorally relevant odors and uncovered functions beyond chemical sensing. Here, we highlight the multifunctional roles of the chemosensory ionotropic receptors in anthropophilic mosquito vectors and suggest future directions to improve our understanding of the IR family.
全球一半的人口面临着由蚊子传播的疾病的威胁。蚊子主要依靠嗅觉来寻找脊椎动物的血液宿主、花蜜来源和合适的产卵地。神经遗传学工具的进步，现在帮助我们理解了介导从人类散发的感觉线索的受体。在嗜人蚊传病媒介埃及伊蚊和冈比亚按蚊的最近研究中，化感离子型受体 (IR) 家族在探测与行为相关的气味方面的作用已被涉及，并揭示了超出化学感应的功能。在这里，我们强调了化感离子型受体在嗜人蚊传病媒介中的多功能作用，并提出了未来的方向，以提高我们对 IR 家族的理解。
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