Matthewson K, Coleridge-Smith P, O'Sullivan J P, Northfield T C, Bown S G
Gastroenterology. 1987 Sep;93(3):550-7. doi: 10.1016/0016-5085(87)90918-8.
The effects of low-power neodymium:yttrium-aluminum-garnet laser light delivered intrahepatically in normal rats have been studied. Power settings of 0.5-2.0 W and exposures of 50-2400 s produced well-defined, highly reproducible necrotic lesions of up to 16 mm in diameter. The diameter of the necrotic lesions depended upon both the power setting and total energy delivered. Histologic examination showed coagulative necrosis that healed by granulation with a small residual fibrous nodule by 60 days. Microthermocouples embedded within the liver indicated temperatures of up to 100 degrees C close to the fiber tip for the higher power settings, and temperatures at the periphery of the necrotic zones were consistent with tissue damage by a purely thermal effect. Radiologic examination of photocoagulated lobes of liver in which arterial tree had been filled with a radiopaque polymer demonstrated loss of all small and some large vessels in the treated area. The technique could be used to induce necrosis of intrahepatic and other tumors.
钇铝石榴石激光经肝内照射正常大鼠的效应进行了研究。功率设置为0.5 - 2.0瓦，照射时间为50 - 2400秒，可产生直径达16毫米的界限清晰、高度可重复的坏死灶。坏死灶的直径取决于功率设置和传递的总能量。组织学检查显示为凝固性坏死，60天时通过肉芽组织愈合，残留一个小的纤维结节。埋置于肝脏内的微热电偶显示，在较高功率设置下，靠近光纤尖端的温度高达100摄氏度，坏死区周边的温度与单纯热效应导致的组织损伤一致。对动脉树已用不透射线聚合物充盈的肝脏光凝叶进行的放射学检查显示，治疗区域内所有小血管和一些大血管均消失。该技术可用于诱导肝内及其他肿瘤的坏死。
