Kaada B, Torsteinbø O
Gen Pharmacol. 1987;18(4):379-84. doi: 10.1016/0306-3623(87)90095-4.
The vasoactive intestinal polypeptide (VIP) is a powerful dilatator in a number of vascular beds. Plasma VIP is increased in active physical exercise and in transcutaneous nerve stimulation. Plasma VIP has in this study been measured during other physiotherapeutic procedures causing skin vasodilatation, such as connective tissue massage and heat packs. Plasma VIP levels and skin temperature of fingers and toes were measured in 12 patients before and at various intervals following a 30 min connective tissue massage. No significant increase in the plasma VIP was found. The same was true in a pilot study using heat pack treatment. It is suggested that somehow VIP is more involved in the vascular response to active physical activity and peripheral nerve stimulation than to passive procedures like connective tissue massage and heat pack treatment.
血管活性肠肽（VIP）在许多血管床中是一种强效扩张剂。在积极的体育锻炼和经皮神经刺激时，血浆VIP会升高。在本研究中，已对其他导致皮肤血管扩张的物理治疗程序（如结缔组织按摩和热敷）期间的血浆VIP进行了测量。在12名患者进行30分钟结缔组织按摩之前及之后的不同时间间隔，测量了他们的血浆VIP水平以及手指和脚趾的皮肤温度。未发现血浆VIP有显著升高。在一项使用热敷治疗的初步研究中也是如此。有人提出，不知何故，VIP在对积极体育活动和外周神经刺激的血管反应中比在对结缔组织按摩和热敷治疗等被动程序的反应中更起作用。
