Laboratory of Systems Neuroscience, Institute for Neuroscience, Department of Health Science and Technology, Swiss Federal Institute of Technology ETH, Zürich, Switzerland.
EMBO J. 2022 Oct 17;41(20):e112383. doi: 10.15252/embj.2022112383. Epub 2022 Sep 13.
Distinct plasticity mechanisms enable neurons to effectively process information also when facing global perturbations in network activity. In this issue of The EMBO Journal, Dubes et al (2022) provide a molecular mechanism whereby individual synapses during periods of chronic inactivity are "tagged" for future strengthening. These results lend further support to the idea that local, nonmultiplicative mechanisms play an important role in homeostatic synaptic plasticity as has been demonstrated for Hebbian-like synaptic plasticity.
当面临网络活动的全局干扰时，不同的可塑性机制使神经元能够有效地处理信息。在本期《欧洲分子生物学组织杂志》中，Dubes 等人提供了一种分子机制，通过该机制，在慢性失活期间，个别突触会被“标记”以备将来增强。这些结果进一步支持了这样一种观点，即局部的、非倍增的机制在稳态突触可塑性中发挥着重要作用，正如在类赫布突触可塑性中所证明的那样。
