Department of Pediatrics, Alexandria University Faculty of Medicine, Alexandria, Egypt.
Turk J Gastroenterol. 2022 Dec;33(12):1058-1061. doi: 10.5152/tjg.2022.21889.
Laboratory markers such as white blood cells, C reactive protein, and erythrocyte sedimentation rate can aid in assessing the activity of inflammatory bowel disease but lacks sensitivity and specificity. Fecal calprotectin has higher sensitivity and specificity but it is expensive. Endoscopy is an invasive, inconvenient procedure having complications. No studies are done concerning the neutrophil/lymphocyte ratio in inflammatory bowel disease in pediatrics. The aim of this study was to assess the neutrophil/lymphocyte ratio as a laboratory marker of inflammatory bowel disease activity and severity in children.
This is a prospective study. The study included all patients from 2 months up to 16 years who were confirmed to have inflammatory bowel disease endoscopically and histopathologically. Clinical activity score and Mayo endoscopic subscore were recorded. Laboratory investigations including white blood cells, C reactive protein, erythrocyte sedimentation rate, and fecal calprotectin were done on all patients. The neutrophil/lymphocyte ratio was calculated and correlated with different activity markers.
We included 50 inflammatory bowel disease patients. The mean neutrophil/lymphocyte ratio in ulcerative colitis was 1.76 ± 0.36, Crohn's disease was 1.50 ± 0.41, and it was 1.47 ± 0.14 in indeterminate colitis. Neutrophil/lymphocyte ratio was significantly correlated to erythrocyte sedimentation rate, C reactive protein, fecal calprotectin, clinical activity score, and Mayo endoscopic subscore.
Neutrophil/lymphocyte ratio can be used as an activity and severity marker in children with inflammatory bowel disease.
白细胞、C 反应蛋白和红细胞沉降率等实验室标志物有助于评估炎症性肠病的活动情况，但缺乏敏感性和特异性。粪便钙卫蛋白具有更高的敏感性和特异性，但价格昂贵。内镜检查是一种有创、不便的操作，存在并发症。目前尚无关于儿科炎症性肠病中性粒细胞/淋巴细胞比值的研究。本研究旨在评估中性粒细胞/淋巴细胞比值作为炎症性肠病儿童活动和严重程度的实验室标志物。
这是一项前瞻性研究。研究纳入了所有经内镜和组织病理学证实为炎症性肠病的 2 个月至 16 岁患者。记录临床活动评分和 Mayo 内镜亚评分。对所有患者进行白细胞、C 反应蛋白、红细胞沉降率和粪便钙卫蛋白等实验室检查。计算中性粒细胞/淋巴细胞比值，并与不同的活动标志物相关联。
我们纳入了 50 例炎症性肠病患者。溃疡性结肠炎的中性粒细胞/淋巴细胞比值平均为 1.76 ± 0.36，克罗恩病为 1.50 ± 0.41，不确定结肠炎为 1.47 ± 0.14。中性粒细胞/淋巴细胞比值与红细胞沉降率、C 反应蛋白、粪便钙卫蛋白、临床活动评分和 Mayo 内镜亚评分显著相关。
中性粒细胞/淋巴细胞比值可作为炎症性肠病儿童的活动和严重程度标志物。
