Wauquier A, Van den Broeck W A, Edmonds H L
Funct Neurol. 1986 Jan-Mar;1(1):53-61.
The sleep-wakefulness (S-W) patterns in 4 genetically epileptic beagles were studied. As compared to normal beagles, there was no change in the percentage time spent in the different stages of S-W. However, epileptic dogs tended towards more and shorter S-W epochs and they had a statistically significant shortening of both REM and deep slow wave sleep (dSWS) latency. The antiepileptics diazepam, phenytoin, flunarizine and phenobarbital did not yield marked effects on S-W patterns, but the REM and dSWS latencies were affected. It is suggested that epileptic beagles may be useful in experimental analysis of epilepsy as well as in drug development.
对4只遗传性癫痫比格犬的睡眠-觉醒（S-W）模式进行了研究。与正常比格犬相比，S-W不同阶段所花费的时间百分比没有变化。然而，癫痫犬的S-W周期往往更多且更短，并且它们的快速眼动（REM）睡眠和深度慢波睡眠（dSWS）潜伏期在统计学上有显著缩短。抗癫痫药物地西泮、苯妥英、氟桂利嗪和苯巴比妥对S-W模式没有显著影响，但REM和dSWS潜伏期受到了影响。有人提出，癫痫比格犬可能在癫痫的实验分析以及药物开发中有用。
