酮的电化学氧化C-C键裂解用于形成C-N键：一种合成酰胺的途径。
Electrochemical Oxidative C-C Bond Cleavage of Ketones for C-N Bond Formation: A Route to Amides.
作者信息
He Yonghui, Zeng Liang, Li Ming, Gu Lijun, Zhang Shengyong, Li Ganpeng
机构信息
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, Yunnan, China.
Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China.
出版信息
J Org Chem. 2022 Oct 7;87(19):12622-12631. doi: 10.1021/acs.joc.2c01025. Epub 2022 Sep 13.
Herein, we report an efficient electrochemical activation of the C-C bond of aryl ketones for the preparation of amides under catalyst- and external-oxidant-free conditions using aliphatic amines as the N source. Under environmentally benign electrolysis conditions, a series of amides were synthesized in good yield. Our control experiments revealed that electricity plays an important role in this transformation.
在此，我们报道了在无催化剂和外部氧化剂的条件下，使用脂肪族胺作为氮源，通过高效的电化学活化芳基酮的碳-碳键来制备酰胺。在环境友好的电解条件下，一系列酰胺以良好的产率被合成出来。我们的对照实验表明，电在这一转化过程中起着重要作用。
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