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Rectally Administrated Thioguanine for Distal Ulcerative Colitis: A Multicenter Case Series.

作者信息

Crouwel Femke, Simsek Melek, van Doorn Amarylle S, Mulder Chris J J, Buiter Hans J C, Barclay Murray L, Florin Timothy H, de Boer Nanne K

机构信息

Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam University Medical Centre, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Departments of Gastroenterology & Clinical Pharmacology, Christchurch Hospital, Canterbury District Health Board and University of Otago, Christchurch, New Zealand.

出版信息

Inflamm Bowel Dis. 2023 Jun 1;29(6):1000-1004. doi: 10.1093/ibd/izac195.

Abstract
摘要

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Thioguanine Therapy in Inflammatory Bowel Diseases. A Practical Guide.
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Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review.
World J Gastroenterol. 2016 Oct 28;22(40):9012-9021. doi: 10.3748/wjg.v22.i40.9012.
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Microbiota: relevant player in thiopurine metabolisation?
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Microbial metabolism of thiopurines: A method to measure thioguanine nucleotides.
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Suppression of p21Rac signaling and increased innate immunity mediate remission in Crohn's disease.
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