高级别胶质瘤放射治疗期间发作活动增加 - 一项前瞻性干预研究的最终结果。
Increasing Seizure Activity During Radiation Treatment for High-grade Gliomas - Final Results of a Prospective Interventional Study.
机构信息
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany;
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
出版信息
In Vivo. 2022 Sep-Oct;36(5):2308-2313. doi: 10.21873/invivo.12961.
BACKGROUND/AIM: Little is known regarding seizures during radiotherapy for brain tumors. This prospective study investigated seizure activity in patients irradiated for high-grade gliomas.
PATIENTS AND METHODS
Using a seizure diary, progression of seizure activity was evaluated in 22 patients receiving chemoradiation for grade III (n=1) or IV (n=21) gliomas. Progression was defined as increased frequency of any and/or generalized seizures (>50%) or increased anti-epileptic medication (≥25%). Patients' satisfaction with the diary was assessed using a questionnaire (six scales of 1-7 points). Uni- and multivariable analyses were performed including baseline seizure activity, age, sex, resection, tumor site, performance score, and history of epilepsy/seizures.
RESULTS
Ten patients (45%) experienced progression of seizure activity during their radiotherapy course, mainly due to increased seizure frequency (nine patients=41%). Mean values of patients' satisfaction scores ranged between 3.92 and 4.92 points.
CONCLUSION
Radiotherapy of high-grade gliomas can increase seizure activity. Patients require close monitoring to initiate or adjust anti-epileptic medication.
背景/目的：关于脑肿瘤放疗期间的癫痫发作知之甚少。本前瞻性研究调查了接受高级别胶质瘤放疗的患者的癫痫活动情况。
患者和方法
使用癫痫日记，对 22 名接受放化疗的 3 级（n=1）或 4 级（n=21）胶质瘤患者的癫痫活动进展进行评估。进展定义为任何和/或全身性癫痫发作频率增加（>50%）或抗癫痫药物增加（≥25%）。使用问卷（六个 1-7 分的量表）评估患者对日记的满意度。进行单变量和多变量分析，包括基线癫痫发作活动、年龄、性别、切除、肿瘤部位、表现评分和癫痫/发作史。
结果
10 名患者（45%）在放疗过程中癫痫活动进展，主要是由于癫痫发作频率增加（9 名患者=41%）。患者满意度评分的平均值在 3.92 到 4.92 分之间。
结论
高级别胶质瘤的放疗会增加癫痫发作的活动。患者需要密切监测，以启动或调整抗癫痫药物。
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