Department of Radiotherapy, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I "Sapienza" University of Rome, Rome, Italy.
In Vivo. 2022 Sep-Oct;36(5):2521-2524. doi: 10.21873/invivo.12988.
This is the case report of a synchronous anal canal cancer and cervical cancer in a patient who underwent definitive chemoradiotherapy (CRT) and radical surgery for anal canal and cervical carcinoma, respectively.
A 55-year-old woman was diagnosed with cT4a cN1 Mx anal canal squamous cell carcinoma and stage IA2 cervical squamous cell carcinoma, based on biopsy and imaging. Definitive CRT consisted of radiotherapy (total dose of 59.4 Gy) and concomitant mitomycin (10 mg/m) and 5-fluorouracil (750 mg/m/5 daily continuous infusion) during the first and last week of radiation. The patient exhibited a complete clinical and radiological response. A radical hysterectomy with pelvic lymphadenectomy was then performed. At the last follow-up (30 months), the patient is still disease-free without any treatment-associated complications.
There is limited information in the literature regarding treatment strategy and outcome of patients with synchronous anal canal and cervical cancer. A two-step treatment, including CRT and radical hysterectomy, is likely to be accepted as valid option.
这是一例同步发生于肛门管和子宫颈的癌症病例报告，患者分别接受了肛门管癌和宫颈癌的根治性放化疗（CRT）和根治性手术。
一名 55 岁女性因活检和影像学检查诊断为 cT4a cN1 Mx 肛门管鳞状细胞癌和 IA2 期子宫颈鳞状细胞癌。采用 CRT 治疗，包括放疗（总剂量 59.4 Gy）和同期丝裂霉素（10 mg/m）和 5-氟尿嘧啶（750 mg/m/5 天持续输注），在放疗的第一周和最后一周进行。患者表现出完全的临床和影像学反应。随后进行根治性子宫切除术和盆腔淋巴结清扫术。在最后一次随访（30 个月）时，患者无疾病且无任何与治疗相关的并发症。
关于同步发生的肛门管和宫颈癌患者的治疗策略和结局，文献中信息有限。两步治疗，包括 CRT 和根治性子宫切除术，可能被认为是有效的选择。
