Bara L, Combe-Tamzali S, Conard J, Horellou M H, Samama M
Haemostasis. 1987;17(3):127-33. doi: 10.1159/000215570.
A new simple clotting test (Heptest) for low molecular weight heparins was compared to anti-Xa determination by an amidolytic assay in volunteers and in patients receiving standard calcium heparin or low molecular weight (LMW) heparin (Enoxaparin) by subcutaneous administration. The results obtained with both methods are in very good agreement. It seems that the Heptest, although influenced by various other clotting parameters, is nevertheless relatively specific for anti-Xa activity. Despite our positive first impression, we object to expressing the results in micrograms of heparin per milliliter or anti-Xa units. Until rigorous standardization is possible, we prefer to express the results as clotting times. Preliminary results warrant a more extensive study in order to assess the clinical relevance of Heptest in patients receiving unfractionated or LMW heparins.
一种用于检测低分子量肝素的新型简易凝血试验（七因子试验），与通过酰胺水解法测定抗Xa活性的方法进行了比较，研究对象为志愿者以及皮下注射标准钙肝素或低分子量（LMW）肝素（依诺肝素）的患者。两种方法所得结果高度一致。七因子试验似乎虽然受其他各种凝血参数影响，但对抗Xa活性仍具有相对特异性。尽管我们有积极的第一印象，但我们反对以每毫升肝素微克数或抗Xa单位来表示结果。在实现严格标准化之前，我们更倾向于以凝血时间来表示结果。初步结果表明有必要进行更广泛的研究，以评估七因子试验在接受普通肝素或低分子量肝素治疗患者中的临床相关性。
