年龄和吸烟状况影响无癌症个体的血清细胞角蛋白 19 片段水平。

Age and Smoking Status Affect Serum Cytokeratin 19 Fragment Levels in Individuals Without Cancer.

机构信息

Medical Research Institute, Kyoto Industrial Health Association, Kyoto, Japan;

Medical Research Institute, Kyoto Industrial Health Association, Kyoto, Japan.

出版信息

In Vivo. 2022 Sep-Oct;36(5):2297-2302. doi: 10.21873/invivo.12959.

DOI:10.21873/invivo.12959

PMID:36099131

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9463925/

Abstract

BACKGROUND/AIM: Lung cancer is a frequent and fatal cancer that is difficult to diagnose in the early stages. CYFRA 21-1 is a serological marker currently used to diagnose and monitor lung cancer; however, its clinical use for screening is controversial. Therefore, the present study investigated the relationship between serum CYFRA 21-1 levels and clinical confounders.

PATIENTS AND METHODS

We recruited 3,674 individuals who had never been diagnosed with any cancer. The relationships between high serum CYFRA 21-1 levels (≥3.5 ng/ml) and age, sex, body mass index, and smoking status were investigated.

RESULTS

High serum CYFRA 21-1 levels (≥3.5 ng/ml) were detected in 5.1% of all subjects. High serum CYFRA 21-1 levels were observed in 7.3% of current smokers and 4.3% of non-smokers. The proportion of subjects with high serum CYFRA 21-1 levels was markedly higher in the older group (65 years and older, 11%) than in the younger group (younger than 45 years, 2.0%). High serum CYFRA 21-1 levels (≥3.5 ng/ml) were associated with older age [odds ratio (OR)=3.39, 95% confidence interval (CI)=1.79-6.41 for 55-64 years vs. <45 years, and OR=7.34, 95% CI=3.86-13.9 for ≥65 years vs. <45 years, respectively] and current smoking (OR=2.09, 95% CI=1.38-3.15 for current smoker vs. non-smoker).

CONCLUSION

High serum CYFRA 21-1 levels were associated with an older age and current smoking, which may be considered as factors influencing CYFRA 21-1 levels.

摘要

背景/目的：肺癌是一种常见且致命的癌症，早期诊断困难。CYFRA 21-1 是一种目前用于诊断和监测肺癌的血清标志物；然而，其用于筛查的临床应用存在争议。因此，本研究调查了血清 CYFRA 21-1 水平与临床混杂因素之间的关系。

患者和方法

我们招募了 3674 名从未被诊断患有任何癌症的个体。研究了高血清 CYFRA 21-1 水平（≥3.5ng/ml）与年龄、性别、体重指数和吸烟状况之间的关系。

结果

所有受试者中，高血清 CYFRA 21-1 水平（≥3.5ng/ml）的检出率为 5.1%。在当前吸烟者和非吸烟者中，高血清 CYFRA 21-1 水平分别为 7.3%和 4.3%。在年龄较大的组（65 岁及以上，11%）中，高血清 CYFRA 21-1 水平的受试者比例明显高于年龄较小的组（<45 岁，2.0%）。高血清 CYFRA 21-1 水平（≥3.5ng/ml）与年龄较大[年龄 55-64 岁与<45 岁相比，比值比（OR）=3.39，95%置信区间（CI）=1.79-6.41；年龄≥65 岁与<45 岁相比，OR=7.34，95% CI=3.86-13.9]和当前吸烟（当前吸烟者与非吸烟者相比，OR=2.09，95% CI=1.38-3.15）相关。