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同一团队在单一三级医疗中心对胎盘植入谱系(PAS)疾病的预期与意外分娩。

Expected Versus Unexpected Delivery for Placenta Accreta Spectrum (PAS) Disorders with Same Team in Single Tertiary Center.

机构信息

University of Health Sciences Tepecik Training and Research Hospital, Department of Perinatology, Izmir, Turkey.

University of Health Sciences Tepecik Training and Research Hospital, Department of Obstetrics and Gynecology, Izmir, Turkey.

出版信息

Z Geburtshilfe Neonatol. 2022 Dec;226(6):391-398. doi: 10.1055/a-1915-5832. Epub 2022 Sep 13.

Abstract

OBJECTIVES

To evaluate the maternal and neonatal outcomes of expected and unexpected pathologically proven placenta accreta spectrum (PAS) cases in a single multidisciplinary center.

MATERIAL AND METHODS

This was a retrospective cohort study of 92 PAS cases from January 2011 until September 2021. Only cases with histopathologically invasive placentation were included in the study. The cases diagnosed at the time of delivery were defined as unexpected PAS (uPAS) and those diagnosed antenatally as expected PAS (ePAS). Maternal and neonatal outcomes of both groups were compared.

RESULTS

Thirty-five (38%) of 92 cases were in the uPAS group. Placenta previa and high-grade PAS (percreata) were significantly higher in the ePAS group (p=0.028, p<0.001; respectively). The mean packed red blood cell transfusion was significantly higher in the uPAS group (p=0.030) but transfusions of other blood products were similar in the two groups. There was no significant difference in intraoperative complication rates between the two groups. Preterm delivery (<37 weeks) was significantly higher in the ePAS group (p<0.001), but there was no significant difference between the two groups in terms of adverse neonatal outcomes.

CONCLUSIONS

Our single center data show that although ePAS cases include more highly invasive PAS cases, maternal hemorrhagic morbidity is lower than uPAS cases. Reducing maternal morbidity in PAS cases can be achieved by increasing antenatal diagnosis.

摘要

目的

评估单一会诊多学科中心中预期和意外经病理证实的胎盘植入谱系(PAS)病例的母婴结局。

材料与方法

这是一项回顾性队列研究,纳入了 2011 年 1 月至 2021 年 9 月期间的 92 例 PAS 病例。仅纳入经组织病理学证实存在侵袭性胎盘植入的病例。在分娩时诊断的病例定义为意外 PAS(uPAS),而在产前诊断的病例定义为预期 PAS(ePAS)。比较两组的母婴结局。

结果

92 例病例中,35 例(38%)为 uPAS 组。ePAS 组的胎盘前置和高级别 PAS(胎盘穿透)明显更高(p=0.028,p<0.001;分别)。uPAS 组的平均红细胞输注量明显更高(p=0.030),但两组间其他血液制品的输注无明显差异。两组术中并发症发生率无显著差异。ePAS 组早产儿(<37 周)发生率明显更高(p<0.001),但两组新生儿不良结局无显著差异。

结论

我们的单中心数据显示,尽管 ePAS 病例中包括更多侵袭性 PAS 病例,但产妇出血发病率低于 uPAS 病例。通过增加产前诊断,可以降低 PAS 病例的产妇发病率。

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