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产科和血液学管理以及计划性或紧急分娩的胎盘植入谱系妇女的结局:黎巴嫩一家公立转诊医院的二次数据分析。

Obstetric and haematological management and outcomes of women with placenta accreta spectrum by planned or urgent delivery: Secondary data analysis of a public referral hospital in Lebanon.

机构信息

Faculty of Health Sciences, Center for Research on Population and Health, American University of Beirut, Beirut, Lebanon.

Department of Obstetrics and Gynecology, Rafik Hariri University Hospital, Beirut, Lebanon.

出版信息

PLoS One. 2024 May 8;19(5):e0302366. doi: 10.1371/journal.pone.0302366. eCollection 2024.

Abstract

BACKGROUND

Lebanon has a high caesarean section use and consequently, placenta accreta spectrum (PAS) is becoming more common.

OBJECTIVES

To compare maternal characteristics, management, and outcomes of women with PAS by planned or urgent delivery at a major public referral hospital in Lebanon.

DESIGN

Secondary data analysis of prospectively collected data.

SETTING

Rafik Hariri University Hospital (public referral hospital), Beirut, Lebanon.

PARTICIPANTS

159 pregnant and postpartum women with confirmed PAS between 2007-2020.

MAIN OUTCOME MEASURES

Maternal characteristics, management, and maternal and neonatal outcomes.

RESULTS

Out of the 159 women with PAS included, 107 (67.3%) underwent planned caesarean delivery and 52 (32.7%) had urgent delivery. Women who underwent urgent delivery for PAS management were more likely to experience antenatal vaginal bleeding compared to those in the planned group (55.8% vs 28.0%, p<0.001). Median gestational age at delivery was significantly lower for the urgent group compared to the planned (34 vs. 36 weeks, p<0.001). There were no significant differences in terms of blood transfusion rates and major maternal morbidity between the two groups; however, median estimated blood loss was significantly higher for women with urgent delivery (1500ml vs. 1200ml, p = 0.011). Furthermore, the urgent delivery group had a significantly lower birth weight (2177.5g vs. 2560g, p<0.001) with higher rates of neonatal intensive care unit (NICU) admission (53.7% vs 23.8%, p<0.001) and perinatal mortality (18.5% vs 3.8%, p = 0.005).

CONCLUSION

Urgent delivery among women with PAS is associated with worse maternal and neonatal outcomes compared to the planned approach. Therefore, early referral of women with known or suspected PAS to specialized centres is highly desirable to maximise optimal outcomes for both women and infants.

摘要

背景

黎巴嫩的剖宫产率较高,因此胎盘植入谱系疾病(PAS)的发病率也越来越高。

目的

比较在黎巴嫩一家主要公立医院中,计划性剖宫产与紧急剖宫产分娩 PAS 患者的产妇特征、处理方法和结局。

设计

对前瞻性收集的数据进行二次数据分析。

地点

拉菲克·哈里里大学医院(公立医院),贝鲁特,黎巴嫩。

参与者

2007 年至 2020 年间确诊为 PAS 的 159 名孕妇和产后妇女。

主要观察指标

产妇特征、处理方法以及母婴结局。

结果

在 159 例 PAS 患者中,107 例(67.3%)行计划性剖宫产分娩,52 例(32.7%)行紧急剖宫产分娩。与计划性组相比,行紧急剖宫产分娩以处理 PAS 的患者产前阴道出血的可能性更高(55.8% vs. 28.0%,p<0.001)。紧急组的中位分娩孕周显著低于计划性组(34 周 vs. 36 周,p<0.001)。两组间输血率和主要产妇发病率无显著差异;然而,紧急分娩组的中位估计失血量显著更高(1500ml vs. 1200ml,p = 0.011)。此外,紧急分娩组的新生儿出生体重显著较低(2177.5g vs. 2560g,p<0.001),新生儿重症监护病房(NICU)入住率更高(53.7% vs. 23.8%,p<0.001),围产儿死亡率也更高(18.5% vs. 3.8%,p = 0.005)。

结论

与计划性剖宫产相比,PAS 患者行紧急剖宫产分娩与更差的母婴结局相关。因此,将已知或疑似 PAS 的患者尽早转诊至专门中心非常重要,这有利于最大限度地提高母婴的最佳结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b138/11078361/e68a56138029/pone.0302366.g001.jpg

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