Deputy Chief Physician, Cardiovascular Surgery of First People's Hospital of Tianshui, Tianshui 741000, China.
Contrast Media Mol Imaging. 2022 Aug 27;2022:5165203. doi: 10.1155/2022/5165203. eCollection 2022.
In order to investigate the expression levels of Lipoprotein A (LPa), B-type Natriuretic Peptide (BNP) and Monocyte chemoattractor Protein-1 (McP-1) in serum of patients with coronary heart disease (CHD) are used to detect significance and to analyze the correlation between these indicators and parameters of echocardiography. The clinical data of 132 CHD patients in our hospital from January 2021 to October 2021 are retrospectively analyzed and included in the CHD group. Another 100 healthy people who came to our hospital for general physical examination were selected as the control group. The expressions of Serum McP-1 and BNP are detected by the ELISA. The expression of Serum LPa is detected by immunoturbidimetry, and the expressions of SERUM McP-1, BNP, and LPa are compared between the two groups. The experiments show that the expressions of McP-1, BNP, and LPa in serum of control group are significantly lower than those of the CHD group ( < 0.05). Echocardiography results show that left ventricular ejection fraction (LVEF) in CHD group is significantly lower than that in control group, but left ventricular end-systolic volume (LVESV) and left ventricular end-diastolic volume (LVEDV) are significantly higher than those in control group ( < 0.05).
为了探讨脂蛋白 A（LPa）、B 型利钠肽（BNP）和单核细胞趋化蛋白-1（McP-1）在冠心病（CHD）患者血清中的表达水平，检测其意义，并分析这些指标与超声心动图参数之间的相关性。回顾性分析了我院 2021 年 1 月至 2021 年 10 月收治的 132 例 CHD 患者的临床资料，将其纳入 CHD 组。另选取 100 例来我院进行常规体检的健康人作为对照组。采用 ELISA 法检测血清 McP-1 和 BNP 的表达，采用免疫比浊法检测血清 LPa 的表达，比较两组患者血清 McP-1、BNP 和 LPa 的表达。实验表明，对照组血清 McP-1、BNP 和 LPa 的表达明显低于 CHD 组（ < 0.05）。超声心动图结果显示，CHD 组左心室射血分数（LVEF）明显低于对照组，而左心室收缩末期容积（LVESV）和左心室舒张末期容积（LVEDV）明显高于对照组（ < 0.05）。
