PhD. Collaborative Researcher, Innovation Center in Salivary Diagnostics and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Universidade Federal de Uberlândia (UFU), Uberlândia (MG), Brazil.
Undergraduate Dentistry Student, School of Dentistry, Universidade Federal de Uberlândia (UFU), Uberlandia (MG), Brazil.
Sao Paulo Med J. 2022 Nov-Dec;140(6):818-828. doi: 10.1590/1516-3180.2021.0816.R2.19052022.
Chronically elevated alpha-2-macroglobulin (A2MG) in the blood has been correlated with diabetes and the HbA1c profile; however, no systematic review has been conducted to evaluate the association of A2MG salivary levels and glycemia or HbA1c levels in diabetes mellitus type 2 (DM2) patients.
To evaluate whether A2MG salivary levels are related to the glycemia or HbA1c levels in DM2 patients.
Systematic review developed at Universidade Federal de Uberlândia (UFU), Brazil.
Eight databases were used as research sources. The eligibility criteria included studies that reported data regarding mean salivary A2MG and the correlation between glycemia and/or HbA1c levels of DM2 subjects (uncontrolled and well-controlled) and non-diabetic subjects. The risk of bias of the studies selected was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools for use in JBI systematic reviews. Pooled correlation coefficients were estimated using the Hunter-Schmidt method. Study estimates were weighted according to their sample size, and heterogeneity was calculated using the chi-square statistic.
Four studies on DM2 patients were included in this systematic review after careful analysis of 1482 studies. Three studies compared A2MG with HbA1c and glycemia. Overall, the correlation between A2MG and HbA1c was strong (r = 0.838). In contrast, the correlation between A2MG and glycemia was low (r = 0.354).
The strong association between HbA1C and salivary A2MG suggests that this salivary protein has the potential to be a surrogate for HbA1C, if corroboratory further evidence is obtained through large-scale studies.
血液中慢性升高的α-2-巨球蛋白（A2MG）与糖尿病和 HbA1c 谱有关；然而，尚未进行系统评价来评估 2 型糖尿病（DM2）患者唾液 A2MG 水平与血糖或 HbA1c 水平的相关性。
评估 DM2 患者的唾液 A2MG 水平是否与血糖或 HbA1c 水平相关。
在巴西联邦大学（UFU）进行的系统评价。
使用了 8 个数据库作为研究来源。纳入标准包括报告有关 DM2 受试者（未控制和控制良好）和非糖尿病受试者的平均唾液 A2MG 以及血糖和/或 HbA1c 水平之间相关性的数据的研究。使用 Joanna Briggs 研究所（JBI）的批判性评估工具评估所选研究的偏倚风险，用于 JBI 系统评价。使用 Hunter-Schmidt 方法估计合并相关系数。根据样本量对研究估计值进行加权，并使用卡方统计计算异质性。
经过对 1482 项研究的仔细分析，本系统评价纳入了 4 项关于 DM2 患者的研究。有 3 项研究将 A2MG 与 HbA1c 和血糖进行了比较。总体而言，A2MG 与 HbA1c 之间的相关性很强（r=0.838）。相比之下，A2MG 与血糖之间的相关性较低（r=0.354）。
如果通过大规模研究获得进一步的佐证证据，HbA1C 与唾液 A2MG 之间的强相关性表明，这种唾液蛋白有可能成为 HbA1C 的替代物。
